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首页> 外文期刊>Interdisciplinary perspectives on infectious diseases >Procalcitonin as a Biomarker for a Bacterial Infection on Hospital Admission: A Critical Appraisal in a Cohort of Travellers with Fever after a Stay in (Sub)tropics
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Procalcitonin as a Biomarker for a Bacterial Infection on Hospital Admission: A Critical Appraisal in a Cohort of Travellers with Fever after a Stay in (Sub)tropics

机译：降钙素原作为细菌入院细菌感染的生物标志物：在（亚）热带地区逗留后发烧的旅行者人群的一项重要评估

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摘要

Fever in a returned traveller may be the manifestation of a self-limiting, trivial infection but it can also presage an infection that can be rapidly progressive and lethal. We studied the diagnostic accuracy of procalcitonin (PCT) as a biomarker for a bacterial cause of fever in a cohort of 157 consecutive travellers with fever after a stay in the (sub)tropics. Elevated procalcitonin levels were observed not only in about 50% of travellers with proven bacterial infection, but also in a significant proportion of travellers with a likely infection. Using a cutoff point of 0.5 ng/mL, procalcitonin had a sensitivity of 0.52 and a specificity of 0.76 for a bacterial cause of fever on admission. Interestingly, only 1 out of 16 patients with a proven viral infection had a marginally elevated PCT concentration on admission, suggesting that an increased PCT level likely excludes a viral infection as the cause of fever. However, the diagnostic accuracy of this semiquantitative procalcitonin test for a bacterial cause of fever on admission is too poor to advocate its use in the initial clinical evaluation of fever in a setting of ill-returned travellers.
机译：返回的旅行者发烧可能是自限性琐碎感染的表现，但也可能预示着可能迅速发展且致命的感染。我们研究了157名连续（亚热带地区）发烧旅行者的队列中降钙素原（PCT）作为细菌性发烧生物标志物的生物标志物的诊断准确性。不仅在大约50％的已证明细菌感染的旅​​行者中观察到降钙素原水平升高，而且在相当一部分可能感染的旅行者中也观察到降钙素原水平升高。使用0.5 ng / mL的临界点，降钙素对入院时细菌性发热的敏感性为0.52，特异性为0.76。有趣的是，在确诊为病毒感染的16位患者中，只有1位患者入院时PCT浓度略有升高，这表明PCT水平升高可能排除了病毒感染作为发烧的原因。但是，这种半定量降钙素原蛋白检测对入院时细菌引起的发热的诊断准确性太差，以至于不能提倡将其用于病情未归的旅行者进行发热的初步临床评估。

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