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首页> 外文期刊>Integrated Pharmacy Research and Practice >Antihypertensive drug prescription patterns and their impact on outcome of blood pressure in Ethiopia: a hospital-based cross-sectional study
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Antihypertensive drug prescription patterns and their impact on outcome of blood pressure in Ethiopia: a hospital-based cross-sectional study

机译：埃塞俄比亚的降压药物处方模式及其对血压结果的影响：一项基于医院的横断面研究

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Background: Irrational prescription is strongly associated with poor control of hypertension. The present study aimed to evaluate antihypertensive drug prescription trends and to measure their impact on the level of blood pressure (BP) control in Gondar University Hospital, Gondar, Ethiopia. Methods: A hospital-based retrospective cross-sectional study was conducted from May 30 to June 30, 2016. All hypertensive patients on medication were included. A structured data abstraction form was prepared to gather the necessary information. The prescription patterns and BP level was measured retrospectively. A binary logistic regression was computed to determine the effect of different prescription patterns on BP control. Results: A total of 596 hypertension patients were recruited for the study; of them, 561(94%) met the study criteria. The mean age of the respondents was 55.96±14.6 years. Females constituted 58.2% of the study population. Approximately fifty percent of the prescriptions were monotherapies. Twice-daily dosing was associated with lower risk of uncontrolled hypertension (crude odds ratio [COR] =0.51[0.15–0.73], adjusted odds ratio [AOR] =0.69[0.163–0.91]). Monthly appointment was linked with a nearly 90% reduced incidence of uncontrolled BP (COR =0.15[0.04–0.73], AOR =0.093[0.024–0.359]). Conclusion: Monotherapies were the most frequently prescribed regimens. Twice-daily dosing and monthly appointments were associated with low incidence of uncontrolled BP. Clinicians should be vigilant in adjusting the frequency of dosing and should fix appointment date in consultation with their patients.
机译：背景：不合理的处方与不良的高血压控制密切相关。本研究旨在评估降压药物处方趋势，并测量其对埃塞俄比亚贡德尔的贡德尔大学医院血压控制水平的影响。方法：于2016年5月30日至2016年6月30日进行了一项基于医院的回顾性横断面研究，纳入了所有接受药物治疗的高血压患者。准备了一个结构化的数据抽象表来收集必要的信息。回顾性地测量处方模式和血压水平。计算了二元逻辑回归，以确定不同处方模式对血压控制的影响。结果：共招募了596例高血压患者。其中，有561名（94％）符合研究标准。受访者的平均年龄为55.96±14.6岁。女性占研究人口的58.2％。大约百分之五十的处方是单一疗法。每天两次给药与较低的无法控制的高血压风险相关（粗体优势比[COR] = 0.51 [0.15-0.73]，调整优势比[AOR] = 0.69 [0.163-0.91]）。每月预约与不受控制的BP发生率降低近90％有关（COR = 0.15 [0.04-0.73]，AOR = 0.093 [0.024-0.359]）。结论：单晶疗法是最常用的治疗方案。每日两次给药和每月约诊与血压失控的发生率低相关。临床医生应保持警惕，调整用药频率，并应与患者协商确定约会日期。

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