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首页> 外文期刊>Integrative Medicine Research >Effectiveness of Electro-acupuncture/Hand-acupuncture Combined with Paroxetine Hydrochloride on Depression: A Pragmatic Randomized Controlled Trial
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Effectiveness of Electro-acupuncture/Hand-acupuncture Combined with Paroxetine Hydrochloride on Depression: A Pragmatic Randomized Controlled Trial

机译：针刺/手刺配合盐酸帕罗西汀治疗抑郁症的疗效：实用随机对照试验

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Purpose: To observe the effectiveness of Electroacupunctureand Hand-acupuncture on depression patientsbased on Patient Reporting Outcome (PRO).Methods: Eighty-eight patients with mild or moderatedepression were randomly divided into three groups: paroxetinegroup (n=35), electroacupuncture+paroxetine group (EA)(n=28) and hand acupuncture +paroxetine group (HA) (n=25).All 88 patients were given antidepressants paroxetine orallyevery morning for 6 weeks (the first two days:10 mg/d, from the third day:20 mg/d). Both EA and HA groupwere added withacupuncture on Baihui(GV20), Yingtang(GV29), Fengchi(GB20),Sanyinjiao(SP6), Neiguan(PC6) and some other acupointsaccording to patients’ different conditions for 30 min everyother day, totally for 6 weeks. The EA group used electricalacupuncture acupoint stimulator (2/15 Hz alternating,LH-202H) at Baihui(GV20), Fengchi(GB20) and Yingtang(GV29).Acupuncture practionors manipulated needles every 15 minand last for 5-10s for each patients in HA group. HamiltonRating Scale for Depression (HAMD) and Measure YourselfMedical Outcome Profile (MYMOP) were used to evaluate theeffectiveness before and after treatment.Results: There was no significant difference among threegroups on the baseline. After six weeks, satistical resultsshowed that HAMD Ratio of points of HA and EA are 92.00%and 89.28% respectively, which were higher than paroxetinegroup (84.71%) (p0.05). The scores in each domain of MYMOPin EA group and HA group were obviously lower than that ofparoxetine group after treatment (p<0.05).Conclusion: Acupuncture significantly reduced the HAMDand MYMOP scores of depression patients. In addition,acupuncture was shown to enhance the effectiveness ofconventional drug treatments and also alleviate the mainsymptoms of depression, thus improving the overall qualityof life and make depression patients felt better themselves.
机译：目的：根据患者报告结果（PRO），观察电针和手刺对抑郁症患者的疗效。方法：将88例轻度或中度抑郁症患者随机分为三组：帕罗西汀组（n = 35），电针+帕罗西汀组（EA）（n = 28）和手针+帕罗西汀组（HA）（n = 25）。88例患者每天早晨口服口服抗抑郁药帕罗西汀，持续6周（前两天：从第三天起每天10 mg / d） ：20mg / d）。 EA组和HA组分别根据患者的病情，分别按每天30分钟分别在百会（GV20），鹰塘（GV29），风池（GB20），三阴交（SP6），内关（PC6）等穴位上加针灸，共6次。周。 EA组在百会（GV20），风池（GB20）和鹰塘（GV29）使用电针穴位刺激器（2/15 Hz交替，LH-202H）。针灸师每15分钟操作一次针头，每位患者持续5-10s医管局小组。用汉密尔顿抑郁量表（HAMD）和测量自己的医疗结果量表（MYMOP）评估治疗前后的疗效。结果：基线的三组间无显着差异。六周后，令人满意的结果显示，HA和EA的HAMD得分分别为92.00％和89.28％，高于帕罗西汀组（84.71％）（p0.05）。 EA组和HA组的MYMOP评分在治疗后均明显低于帕罗西汀组（p <0.05）。结论：针刺可明显降低抑郁症患者的HAMD和MYMOP评分。此外，针灸被证明可以提高常规药物治疗的有效性，并减轻抑郁症的主要症状，从而改善整体生活质量，并使抑郁症患者感觉更好。

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