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首页> 外文期刊>Integrative Medicine Research >Effect of Electro-acupuncture Intervention on Learning-memory Ability and Hippocampus Ultrastructure in APP/PS1 Double Transgenic Rats
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Effect of Electro-acupuncture Intervention on Learning-memory Ability and Hippocampus Ultrastructure in APP/PS1 Double Transgenic Rats

机译：电针干预对APP / PS1双转基因大鼠学习记忆能力和海马超微结构的影响

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Purpose: To investigate the effects of the electroacupuncture(EA) for APP/PS1 double transgenic rat on bothspatial learning- memorize behavior and hippocampal ultrastructure.Methods: Divide 36 4-month-old APP/PS1 double transgenicrats into 3 groups, which are the model group, theEA group and the drug(AChE) group, by using the randomassignment method. 12 4-month-old rats with brood recessivegene were taken as the control group. For the EA group,“Baihui”(GV20) and “yongquan”(KI1) were given treatment for15 minutes every other day, lasting for 5 weeks. Gavaging with0.92 ml/g of acetylcholine enzymewas given to the drug group.Test the learning-memorize ability and space exploration abilityof the rats by using the Morriswater maze. Observe slices ofthe brain hippocampus CA1 area with transmission electronmicroscope.
机译：目的：研究电针对APP / PS1双转基因大鼠的空间学习记忆行为和海马超微结构的影响。方法：将36只4个月大的APP / PS1双转基因大鼠分为3组，分别为模型组，EA组和药物（AChE）组，采用随机分配方法。将12只4个月大的具有窝隐性基因的大鼠作为对照组。对于EA组，“百会”（GV20）和“永泉”（KI1）每隔一天治疗15分钟，持续5周。给该药物组灌胃0.92 ml / g乙酰胆碱酶。用莫里斯沃特迷宫测试大鼠的学习记忆能力和空间探索能力。用透射电子显微镜观察脑海马CA1区的切片。

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