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首页> 外文期刊>Intensive Care Medicine Experimental >Granulocyte and monocyte adsorptive apheresis ameliorates sepsis in rats
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Granulocyte and monocyte adsorptive apheresis ameliorates sepsis in rats

机译：粒细胞和单核细胞吸附性单采血液分离改善大鼠败血症

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BackgroundOverwhelming activation of granulocytes and monocytes is central to inflammatory responses during sepsis. Granulocyte and monocyte adsorptive apheresis (GMA) is an extracorporeal leukocyte apheresis device filled with cellulose acetate beads and selectively adsorbs granulocytes and monocytes from the peripheral blood. MethodsIn this study, septic rats received the GMA treatment for 2?h at 18?h after cecal ligation and puncture. ResultsGMA selectively adsorbed activated neutrophils and monocytes from the peripheral blood, reduced serum inflammatory cytokine expression, and seemed to improve organ injuries and animal survival. GMA potentially reduced lung injury by alleviating the infiltration of inflammatory cells and the secretion of cytokines. ConclusionsThis study showed that selective granulocyte and monocyte adsorption with cellulose acetate beads might ameliorate cecal ligation and puncture (CLP)-induced sepsis and improve survival and organ function.
机译：背景粒细胞和单核细胞的压倒性激活是败血症期间炎症反应的关键。粒细胞和单核细胞吸附性单采血液分离术（GMA）是一种充满醋酸纤维素珠的体外白细胞单采血液分离术，可选择性吸附外周血中的粒细胞和单核细胞。方法在本研究中，脓毒症大鼠在盲肠结扎和穿刺后的18？h接受GMA治疗2？h。结果GMA从外周血中选择性吸附了活化的嗜中性粒细胞和单核细胞，降低了血清炎性细胞因子的表达，似乎改善了器官损伤和动物存活率。 GMA可能通过减轻炎症细胞的浸润和细胞因子的分泌来减轻肺损伤。结论：这项研究表明，醋酸纤维素珠粒对粒细胞和单核细胞的选择性吸附可改善盲肠结扎和穿刺（CLP）引起的败血症，并改善存活率和器官功能。

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