...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Intensive Care Medicine Experimental >Systemic and microcirculatory effects of blood transfusion in experimental hemorrhagic shock
【24h】

Systemic and microcirculatory effects of blood transfusion in experimental hemorrhagic shock

机译：失血性休克时输血的全身和微循环作用

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BackgroundThe microvascular reperfusion injury after retransfusion has not been completely characterized. Specifically, the question of heterogeneity among different microvascular beds needs to be addressed. In addition, the identification of anaerobic metabolism is elusive. The venoarterial PCO2 to arteriovenous oxygen content difference ratio (Pv-aCO2/Ca-vO2) might be a surrogate for respiratory quotient, but this has not been validated. Therefore, our goal was to characterize sublingual and intestinal (mucosal and serosal) microvascular injury after blood resuscitation in hemorrhagic shock and its relation with O2 and CO2 metabolism. MethodsAnesthetized and mechanically ventilated sheep were assigned to stepwise bleeding and blood retransfusion ( n =?10) and sham ( n =?7) groups. We performed analysis of expired gases, arterial and mixed venous blood gases, and intestinal and sublingual videomicroscopy. ResultsIn the bleeding group during the last step of hemorrhage, and compared to the sham group, there were decreases in oxygen consumption (3.7 [2.8–4.6] vs. 6.8 [5.8–8.0] mL?min?1?kg?1, P P v-aCO2/Ca-vO2 increased in the last step of bleeding (2.4 [2.0–2.8] vs. 1.1 [1.0–1.3], P P v-aCO2/Ca-vO2 had a weak correlation with respiratory quotient (Spearman R =?0.42, P ConclusionsAlthough there were some minor differences, intestinal and sublingual microcirculation behaved similarly. Therefore, sublingual mucosa might be an adequate window to track intestinal microvascular reperfusion injury. Additionally, Pv-aCO2/Ca-vO2 was poorly correlated with respiratory quotient, and its physiologic behavior was different. Thus, it might be a misleading surrogate for anaerobic metabolism.
机译：背景输血后的微血管再灌注损伤尚未完全表征。具体而言，需要解决不同微血管床之间的异质性问题。此外，厌氧代谢的鉴定还很困难。静脉动脉PCO 2 与动静脉血氧含量的差异比（P va CO 2 / C av O 2 ）可能是呼吸商的替代物，但这尚未得到验证。因此，我们的目标是表征失血性休克血液复苏后舌下和肠道（粘膜和浆膜）微血管损伤及其与O 2 和CO 2 代谢的关系。方法将经麻醉和机械通气的绵羊分为逐步出血和输血（n = 10）和假（n = 7）组。我们对呼出气体，动脉和混合静脉血气体以及肠和舌下视频显微镜进行了分析。结果在出血的最后一步，与假手术组相比，氧气消耗量减少了（3.7 [2.8-4.6] mL vs. 6.8 [5.8-8.0] mL？min ？1 ？kg ？1 ，PP va CO 2 / C av O 2 增加出血的最后一步（2.4 [2.0–2.8]与1.1 [1.0–1.3]，PP va CO 2 / C av O 2 与呼吸商的相关性较弱（Spearman R =？0.42，P结论）尽管存在一些细微差异，但肠和舌下微循环的表现相似，因此，舌下粘膜可能是追踪肠微血管再灌注损伤的合适窗口。 ，P va CO 2 / C av O 2 与呼吸商的相关性较弱，其生理行为为因此，这可能是对厌氧代谢的一种误导性替代。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号