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首页> 外文期刊>Intensive Care Medicine Experimental >The respiratory pressure—abdominal volume curve in a porcine model
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The respiratory pressure—abdominal volume curve in a porcine model

机译：猪模型中的呼吸压力-腹部容积曲线

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BackgroundIncreasing intra-abdominal volume (IAV) can lead to intra-abdominal hypertension (IAH) or abdominal compartment syndrome. Both are associated with raised morbidity and mortality. IAH can increase airway pressures and impair ventilation. The relationship between increasing IAV and airway pressures is not known. We therefore assessed the effect of increasing IAV on airway and intra-abdominal pressures (IAP). MethodsSeven pigs (41.4 +/?8.5?kg) received standardized anesthesia and mechanical ventilation. A latex balloon inserted in the peritoneal cavity was inflated in 1-L increments until IAP exceeded 40?cmH2O. Peak airway pressure (pPAW), respiratory compliance, and IAP (bladder pressure) were measured. Abdominal compliance was calculated. Different equations were tested that best described the measured pressure-volume curves. ResultsAn exponential equation best described the measured pressure-volume curves. Raising IAV increased pPAW and IAP in an exponential manner. Increases in IAP were associated with parallel increases in pPAW with an approximate 40% transmission of IAP to pPAW. The higher the IAP, the greater IAV effected pPAW and IAP. ConclusionsThe exponential nature of the effect of IAV on pPAW and IAP implies that, in the presence of high grades of IAH, small reductions in IAV can lead to significant reductions in airway and abdominal pressures. Conversely, in the presence of normal IAP levels, large increases in IAV may not affect airway and abdominal pressures.
机译：背景腹腔内容积（IAV）的增加可能导致腹腔内高血压（IAH）或腹腔室综合征。两者均与发病率和死亡率升高有关。 IAH会增加呼吸道压力并损害通风。 IAV增加与气道压力之间的关系尚不清楚。因此，我们评估了增加IAV对气道和腹腔内压力（IAP）的影响。方法对7头猪（41.4±8.5kg）进行标准化麻醉和机械通气。插入腹膜腔的乳胶气球以1 L的增量膨胀，直到IAP超过40？cmH 2 O。测量峰值气道压力（pP AW ），呼吸顺应性和IAP（膀胱压力）。计算腹部顺应性。测试了不同的方程，可以最好地描述测得的压力-体积曲线。结果一个指数方程最能描述测得的压力-体积曲线。增加IAV以指数方式增加了pP AW 和IAP。 IAP的增加与pP AW 的平行增加相关，IAP向pP AW 的传播约为40％。 IAP越高，IAV对pP AW 和IAP的影响越大。结论IAV对pP AW 和IAP的影响具有指数性质，这表明，在存在高水平的IAH的情况下，IAV的少量降低可导致气道和腹压的显着降低。相反，在IAP正常的情况下，IAV的大幅增加可能不会影响气道和腹部的压力。

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