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首页> 外文期刊>Internal medicine. >Expression of Master Regulators of T-cell, Helper T-cell and Follicular Helper T-cell Differentiation in Angioimmunoblastic T-cell Lymphoma
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Expression of Master Regulators of T-cell, Helper T-cell and Follicular Helper T-cell Differentiation in Angioimmunoblastic T-cell Lymphoma

机译：血管免疫母细胞性T细胞淋巴瘤中T细胞，辅助性T细胞和滤泡性辅助性T细胞分化的主要调控因子的表达

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Objective It has been postulated that the normal counterpart of angioimmunoblastic T-cell lymphoma (AITL) is the follicular helper T-cell (TFH). Recent immunological studies have identified several transcription factors responsible for T-cell differentiation. The master regulators associated with T-cell, helper T-cell (Th), and TFH differentiation are reportedly BCL11B, Th-POK, and BCL6, respectively. We explored the postulated normal counterpart of AITL with respect to the expression of the master regulators of T-cell differentiation. Methods We performed an immunohistochemical analysis in 15 AITL patients to determine the expression of the master regulators and several surface markers associated with T-cell differentiation. Results BCL11B was detected in 10 patients (67%), and the surface marker of T-cells (CD3) was detected in all patients. Only 2 patients (13%) expressed the marker of na?ve T-cells (CD45RA), but all patients expressed the marker of effector T-cells (CD45RO). Nine patients expressed Th-POK (60%), and 7 (47%) expressed a set of surface antigens of Th (CD4-positive and CD8-negative). In addition, BCL6 and the surface markers of TFH (CXCL13, PD-1, and SAP) were detected in 11 (73%), 8 (53%), 14 (93%), and all patients, respectively. Th-POK-positive/BCL6-negative patients showed a significantly shorter overall survival (OS) than the other patients (median OS: 33.0 months vs. 74.0 months, p=0.020; log-rank test). Conclusion Many of the AITL patients analyzed in this study expressed the master regulators of T-cell differentiation. The clarification of the diagnostic significance and pathophysiology based on the expression of these master regulators in AITL is expected in the future.
机译：目的假定血管免疫性T细胞淋巴瘤（AITL）的正常对应物是卵泡辅助性T细胞（TFH）。最近的免疫学研究已经鉴定出几种负责T细胞分化的转录因子。据报道，与T细胞，辅助T细胞（Th）和TFH分化相关的主调节剂分别为BCL11B，Th-POK和BCL6。我们探讨了假定的正常的AITL对应的T细胞分化的主要监管机构的表达。方法我们对15例AITL患者进行了免疫组织化学分析，以确定主调节剂的表达以及与T细胞分化相关的几种表面标志物。结果10例患者中检出BCL11B（67％），所有患者均检测到T细胞表面标志物（CD3）。仅2例患者（13％）表达了天然T细胞的标志物（CD45RA），但所有患者均表达了效应T细胞的标志物（CD45RO）。 9名患者表达Th-POK（60％），而7名（47％）表达一系列Th表面抗原（CD4阳性和CD8阴性）。此外，分别在11例（73％），8例（53％），14例（93％）和所有患者中检测到BCL6和TFH的表面标记（CXCL13，PD-1和SAP）。 Th-POK阳性/ BCL6阴性患者的总生存期（OS）明显短于其他患者（中位OS：33.0个月比74.0个月，p = 0.020;对数秩检验）。结论在本研究中分析的许多AITL患者都表达了T细胞分化的主要调控因子。预计将来会基于这些主调节剂在AITL中的表达来阐明诊断意义和病理生理学。

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