Development of Epstein-Barr Virus-related Primary Diffuse Large B-cell Lymphoma of the Central Nervous System in a Patient with Peripheral T-cell Lymphoma, Not Otherwise Specified after Mogamulizumab Treatment

Hiroaki Tanaka; Hanako Aoki; Yasumasa Sugita; Ryo Shimizu; Katsunari Kiko; Hidetoshi Mochida; Yoshio Suzuki

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Development of Epstein-Barr Virus-related Primary Diffuse Large B-cell Lymphoma of the Central Nervous System in a Patient with Peripheral T-cell Lymphoma, Not Otherwise Specified after Mogamulizumab Treatment

机译：周围型T细胞淋巴瘤患者中爱泼斯坦巴尔病毒相关的原发性弥漫性大B细胞淋巴瘤的中枢神经系统的发展，莫加木单抗治疗后未另行指明

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Mogamulizumab is a defucosylated humanized anti-CC chemokine receptor type 4 (CCR4) antibody that exerts an anti-tumor immune effect against various tumors through a suppressive effect on regulatory T-cells. We herein report a patient with peripheral T-cell lymphoma who developed Epstein-Barr virus (EBV)-related primary diffuse large B-cell lymphoma of the central nervous system (CNS DLBCL) after mogamulizumab therapy. Our experience should alert physicians to the possibility of the development of EBV-related CNS DLBCL in patients treated for primary lymphoma and suggests that the anti-tumor immune effect of mogamulizumab is ineffective for the prophylaxis of EBV-related lymphomas.

机译：Mogamulizumab是一种去岩藻糖基化的人源化抗CC趋化因子受体4型（CCR4）抗体，通过抑制调节性T细胞发挥抗肿瘤免疫作用。我们在此报告了mogamulizumab治疗后发展为爱泼斯坦-巴尔病毒（EBV）相关的原发性中枢神经系统弥漫性大B细胞淋巴瘤（CNS DLBCL）的外周T细胞淋巴瘤患者。我们的经验应提醒医生注意原发性淋巴瘤患者中可能出现与EBV相关的CNS DLBCL的发展，并提示莫加莫珠单抗的抗肿瘤免疫作用对于预防EBV相关的淋巴瘤无效。

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《Internal medicine.》 |2017年第20期|共5页
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Hiroaki Tanaka; Hanako Aoki; Yasumasa Sugita; Ryo Shimizu; Katsunari Kiko; Hidetoshi Mochida; Yoshio Suzuki;
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1. Epstein-Barr virus-related diffuse large B-cell lymphoma in mogamulizumab-treated adult T-cell leukemia with incomplete T-cell reconstitution [J] . Kamachi Kazuharu, Shindo Takero, Miyahara Masaharu, International journal of hematology . 2019,第2期

机译：与莫伐罂粟属治疗的成人T细胞白血病的Epstein-BARR病毒相关的弥漫性大B细胞淋巴瘤，具有不完全T细胞重建
2. Primary cutaneous, composite, Epstein-Barr virus-associated, diffuse large B-cell lymphoma and peripheral T-cell lymphoma. [J] . Papalas JA, Puri PK, Sebastian S, American Journal of Dermatopathology . 2011,第7期

机译：原发性皮肤，复合性，与爱泼斯坦-巴尔病毒相关的弥漫性大B细胞淋巴瘤和周围性T细胞淋巴瘤。
3. Epstein-Barr virus-associated primary central nervous system lymphoma in a patient with adult T-cell leukemia / lymphoma. [J] . Amano M, Marutsuka K, Sugimoto T, The Journal of dermatology . 2011,第6期

机译：成年T细胞白血病/淋巴瘤患者中与爱泼斯坦巴尔病毒相关的原发性中枢神经系统淋巴瘤。
4. Mutational profile of Diffuse Large B-cell Lymphoma with central nervous system relapse: analysis of CBioPortal for Cancer Genomics database [C] . Elena Voropaeva, Olga Beresina, Tatyana Pospelova, Conference on Cognitive Sciences, Genomics and Bioinformatics . 2020

机译：弥漫性大B细胞淋巴瘤与中枢神经系统复发的突变特征：用于癌症基因组学数据库的CBioPortal分析
5. Safety and Efficacy of the Immunomodulatory Drug (IMiD) Lenalidomide in Patients with Lymphoma: Development of RU051417I - Phase I/II Open-Label Study of R-ICE (Rituximab-Ifosfamide-Carboplatin-Etoposide) with Lenalidomide [R2-ICE] in Patients with First-Relapse/Primary Refractory Diffuse Large B-Cell Lymphoma (DLBCL). [D] . Kasi, Pashtoon Murtaza. 2018

机译：免疫调节药物来那度胺在淋巴瘤患者中的安全性和有效性：RU051417I-R-ICE（利妥昔单抗-异环磷酰胺-卡铂-依托泊苷）与来那度胺[R2-ICE]的I / II期开放标签研究的进展初次复发/原发性难治性弥漫性大B细胞淋巴瘤（DLBCL）。
6. Development of Epstein-Barr Virus-related Primary Diffuse Large B-cell Lymphoma of the Central Nervous System in a Patient with Peripheral T-cell Lymphoma Not Otherwise Specified after Mogamulizumab Treatment [O] . Hiroaki Tanaka, Hanako Aoki, Yasumasa Sugita, 2017

机译：外周T细胞淋巴瘤患者中爱泼斯坦-巴尔病毒相关的原发性弥漫性大B细胞淋巴瘤的中枢神经系统的发展莫加米珠单抗治疗后未另行指明
7. The development of peripheral T-cell lymphoma after successful treatment for diffuse large B-cell lymphoma in a patient with suspected adult onset immunodeficiency: more questions than answers? [O] . M. F. Kilner, S. Merante, A. Svec 2013

机译：在患有疑似成人发病免疫缺陷的患者中成功治疗后外周T细胞淋巴瘤的发育：更多的问题而不是答案？

Development of Epstein-Barr Virus-related Primary Diffuse Large B-cell Lymphoma of the Central Nervous System in a Patient with Peripheral T-cell Lymphoma, Not Otherwise Specified after Mogamulizumab Treatment

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