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首页> 外文期刊>International Journal Bioautomation >Specific Antitumor Effect of the Combined Action of Algal Heteropolysaccharide and Electroporation
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Specific Antitumor Effect of the Combined Action of Algal Heteropolysaccharide and Electroporation

机译：藻类杂多糖与电穿孔联合作用的特异性抗肿瘤作用

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摘要

Marine organisms are potentially prolific sources of highly bioactive secondary metabolites that might represent useful leads in the development of new pharmaceutical agents. In this study the biological effect of the freeze-dried heteropolysaccharide, isolated and purified from the red microalga Rhodella reticulata strain using electroporation was evaluated. Two different types of cells - tumor and non-tumor were treated with the heteropolysaccharide alone or together with the application of electroporation. The effect of the treatment was evaluated in parallel: with proliferation test for estimating cell viability and with immunofluorescent cytoskeleton staining to establish changes in morphology. Evidence for cell line specific viability reduction (70% from the control in case of cancer cell line treatment and only 30% in non-tumor cells) in a dose dependent manner was presented. These findings will arouse further interest in heteropolysaccharide as a new anticancer drug suitable for clinical trials.
机译：海洋生物是高生物活性次级代谢物的潜在多产来源，可能代表了开发新药剂的有用线索。在这项研究中，评估了使用电穿孔技术从红色微藻网状红球菌菌株中分离和纯化的冷冻干燥杂多糖的生物学效应。两种不同类型的细胞-肿瘤细胞和非肿瘤细胞分别用杂多糖处理或与电穿孔一起处理。平行评价治疗效果：用增殖试验估计细胞活力，用免疫荧光细胞骨架染色确定形态变化。提出了以剂量依赖性方式降低细胞系特异性生存力的证据（在癌细胞系治疗的情况下为对照的70％，在非肿瘤细胞中仅为30％）。这些发现将引起人们对杂多糖作为适用于临床试验的新抗癌药物的进一步兴趣。

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