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首页> 外文期刊>International Journal of Basic & Clinical Pharmacology >The role of losartan and enalapril in the protection against stress-induced gastric mucosal ulceration in rats
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The role of losartan and enalapril in the protection against stress-induced gastric mucosal ulceration in rats

机译：氯沙坦和依那普利在预防应激性胃黏膜溃疡中的作用

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Background: Angiotensin II (ANG II) is a stress hormone and its level dramatically increases in the stomach during stress. In addition, it generates reactive oxygen species (ROS) with cellular damage and inflammation. So the aim of this study is to evaluate the mechanism of losartan and enalapril in the prevention of stress-induced gastric ulcer through their action on mucosal prostaglandin (PGs) and antioxidant enzymes and compare between them. Methods: Thirty- six adult male wistar albino rats weighing 180-200 g were divided into 6 groups; n= 6. Groups 1, 2, and 3 were received saline (normal control), losartan (3 mg/kg/day) and enalapril (10 mg/kg/day) i.p respectively for 4 weeks. Groups 4, 5, and 6 were pretreated with saline (ulcer control), losartan (3 mg/kg/day) and enalapril (10 mg/kg/day) i.p respectively for 4 weeks duration. On 29th day, group 4, 5 and 6 were submitted to gastric ulcer by water immersion method, then animals of all groups were sacrificed, stomachs were excised for gross and microscopic examination and determination of the mucosal levels of prostaglandin E2 (PGE2), superoxide dismutase (SOD), nitric oxide (NO) and catalase (CAT). Results: Stress produced gastric ulcer and a significant decrease in all measured gastric parameters compared to normal control group. Pre-treatment of rats with losartan or enalapril decreased the stress-induced alterations in mucosal parameters, but only losartan caused a significant increase in CAT activity in addition. Conclusions: Antagonize the action of ANG II by losartan and enalapril have preventive advantages in stress-induced gastric ulcer and losartan has better influence as it has an additional effect on CAT activity.
机译：背景：血管紧张素II（ANG II）是一种压力激素，在压力期间其在胃中的含量会急剧增加。此外，它会产生具有细胞损伤和炎症的活性氧（ROS）。因此，本研究的目的是评估氯沙坦和依那普利通过对粘膜前列腺素（PGs）和抗氧化酶的作用来预防应激性胃溃疡的机制，并进行比较。方法：将36只体重为180-200 g的成年雄性维斯塔白化雄性大鼠分为6组;每组10只。 n ＝ 6。第1、2和3组分别腹腔注射生理盐水（正常对照组），氯沙坦（3mg / kg /天）和依那普利（10mg / kg /天），持续4周。第4、5和6组分别腹腔注射生理盐水（溃疡控制），氯沙坦（3 mg / kg /天）和依那普利（10 mg / kg /天）预处理4周。第29天，第4、5和6组通过水浸法治疗胃溃疡，然后处死所有组的动物，切下胃进行肉眼和显微镜检查，并测定前列腺素E2（PGE2），超氧化物的黏膜水平。歧化酶（SOD），一氧化氮（NO）和过氧化氢酶（CAT）。结果：与正常对照组相比，压力产生了胃溃疡，并且所有测得的胃参数均显着下降。用氯沙坦或依那普利对大鼠进行预处理可降低应激引起的粘膜参数改变，但只有氯沙坦可引起CAT活性显着增加。结论：氯沙坦和依那普利拮抗ANG II的作用在应激性胃溃疡中具有预防优势，氯沙坦对CAT活性具有附加作用，因此具有更好的影响。

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