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首页> 外文期刊>International Journal of Basic & Clinical Pharmacology >Evaluation of anticonvulsant activity of ACE inhibitors (imidapril and quinapril) in experimentally induced animal models of epilepsy
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Evaluation of anticonvulsant activity of ACE inhibitors (imidapril and quinapril) in experimentally induced animal models of epilepsy

机译：在实验诱导的癫痫动物模型中评估ACE抑制剂（咪达普利和奎那普利）的抗惊厥活性

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Background: Epilepsy is a chronic neurological disorder characterized by an enduring predisposition to generate seizures, may be associated with emotional and cognitive dysfunction. Objective of this study was to evaluate and compare the anticonvulsant activity of different doses of imidapril and quinapril in animal models of epilepsy. Methods: Swiss albino mice weighing around 25-30g of either sex were divided into 6 groups: control (R.O-10 ml/kg), standard-sodium valproate (40 mg/kg), Q1-quinapril (1.5 mg/kg), Q2-quinapril (10.4 mg/kg), I1-imidapril (0.65mg/kg) and I2-imidapril (2.6 mg/kg). 1 hour after administration of control, test and standard drugs (orally) test was conducted. Convulsions were induced by administering PTZ (70 mg/kg-i.p.) in PTZ model. Seizure latency was the parameter recorded. In MES model, maximal seizures were evoked by supra maximal electroshock stimulation of 50 mA, 50 HZ for 0.2 seconds by using conventional electro convulsion meter. Suppression of tonic hind limb extension was taken as measure of efficacy. Results: The results were analysed by one-way-ANOVA followed by Bonferroni's multiple comparison test. In MES test, dose dependently quinapril and imidapril significantly reduced the duration of tonic hind limb extension in comparison to control (p Conclusions: Quinapril and imidapril in a dose dependent manner showed increase in antiepileptic activity, imidapril has better antiepileptic activity when compared to quinapril.
机译：背景：癫痫病是一种慢性神经系统疾病，其特征是持久的易诱发癫痫发作的倾向，可能与情绪和认知功能障碍有关。本研究的目的是评估和比较不同剂量的咪达普利和喹那普利在癫痫动物模型中的抗惊厥活性。方法：将体重约25-30g的瑞士白化病小鼠分为6组：对照组（RO-10 ml / kg），标准丙戊酸钠（40 mg / kg），Q1-喹那普利（1.5 mg / kg）， Q2-奎那普利（10.4 mg / kg），I1-吡虫啉（0.65mg / kg）和I2-吡虫啉（2.6 mg / kg）。在给予对照后1小时，进行测试和标准药物（口服）测试。通过在PTZ模型中服用PTZ（70 mg / kg-i.p。）诱发惊厥。癫痫潜伏期是记录的参数。在MES模型中，通过使用常规电惊厥仪对50mA，50HZ的超最大电击刺激0.2秒引起最大癫痫发作。抑制补品后肢伸展作为疗效的量度。结果：通过单因素方差分析，然后进行Bonferroni多重比较测试，分析结果。在MES测试中，与对照组相比，剂量依赖性的奎纳普利和咪唑普利显着减少了补品后肢伸展的持续时间（p结论：奎那普利和咪达普利以剂量依赖性方式显示出抗癫痫活性增加，与奎尼普利相比，咪达普利具有更好的抗癫痫活性。

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