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首页> 外文期刊>International Journal of Basic & Clinical Pharmacology >Evaluation of analgesic activity of Ficus racemosa leaf extract using acetic acid induced writhing method in mice
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Evaluation of analgesic activity of Ficus racemosa leaf extract using acetic acid induced writhing method in mice

机译：醋酸诱导扭体法评价小花榕叶提取物的镇痛活性

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Background: To evaluate the analgesic activity of Ficus racemosa leaf extract and its comparison with standard drug using acetic acid induced writhing method in mice. Methods: Chloroform extract of leaves was obtained using soxhlet apparatus. Isolated fraction of extract (FRE) was used for the experiments. Swiss albino mice of either sex, average weight 20-25 gms were used for experiments. Animals were divided into 6 groups consisting of 6 animals each.1% acetic acid was administered intra peritoneally to the experimental animals to create pain sensation. Each group received particular treatment 30 minutes prior to administration of acetic acid. Each mouse of all groups were observed individually for counting number of writhes they made in 15 minutes commencing just 5 minutes after the administration of acetic acid. Diclofenac was taken as standard drug. Results: FRE at the dose of 50 mg/kg did not shows any significant analgesic activity while at the dose of 100 and 200 mg/kg it showed significant analgesic activity as compare to control group. FRE at dose of 200 mg/kg showed significant analgesic activity as compare to diclofenac in writhing model. Diclofenac in combination with 50 mg/kg dose of FRE produced significant analgesic activity when compared to control value or either treatment alone. Conclusions: FRE endowed with peripheral analgesic properties in dose dependent manner. And also enhances the analgesic effect of diclofenac. However further study is needed in order to understand the precise mechanism.
机译：背景：评价榕榕叶提取物的镇痛活性及其与醋酸诱导扭体法与标准药物的比较。方法：使用索氏提取仪获得叶的氯仿提取物。提取物的分离级分（FRE）用于实验。实验使用平均体重20-25克的雌雄同体的瑞士白化病小鼠。将动物分为6组，每组6只动物。对实验动物腹膜内给予1％乙酸以产生疼痛感。每组在给予乙酸之前30分钟接受特殊治疗。单独观察所有组的每只小鼠，以计数它们在施用乙酸后仅5分钟开始的15分钟内产生的打数。双氯芬酸被视为标准药物。结果：FRE在50 mg / kg的剂量下没有显示出明显的镇痛活性，而在100和200 mg / kg的剂量下与对照组相比则显示出明显的镇痛活性。与扭索模型中的双氯芬酸相比，剂量为200 mg / kg的FRE具有明显的镇痛活性。与对照值或单独使用任一治疗相比，双氯芬酸与50 mg / kg剂量的FRE联合产生明显的镇痛活性。结论：FRE具有剂量依赖性的外周镇痛作用。并且还增强了双氯芬酸的镇痛作用。但是，需要进一步的研究以了解精确的机制。

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