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首页> 外文期刊>International Journal of Basic & Clinical Pharmacology >Treatment of severe falciparum malaria: quinine versus artesunate
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Treatment of severe falciparum malaria: quinine versus artesunate

机译：严重恶性疟疾的治疗：奎宁与青蒿琥酯

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Background: Malaria is the most important disease of human being. More than 40% of the world's population is considered to be at risk of exposure of this disease. Malaria infection has been increasing over recent years due to combination of factors including increasing resistance of malarial parasite. Most of the strains of P. falciparum are now resistance to conventional drugs like chloroquine in many areas. The objective of this study was to compare the efficacy and safety of quinine and artesunate in treatment of P. falciparum malaria. Methods: This is hospital based prospective study, conducted amongst 35 randomly selected patients of severe P. falciparum malaria. Patients with any contraindications of either drug were excluded to avoid bias. Standard statistical tests were applied for qualitative as well as quantitative data. Results: As per the study end point results of difference of mortality in patients receiving either drug was not significant (p > 0.75), but difference in clinical parameters like fever clearance time (p Conclusions: Artesunate is as good as quinine in mortality aspect but artesunate is superior in fever clearance time (FCT) & parasite clearance time (PCT). Coma resolution time is faster with quinine as compared to artesunate. There are no significant adverse effects of either drug. So artesunate is equivalent or superior for treatment for severe falciparum malaria.
机译：背景：疟疾是人类最重要的疾病。据认为，世界上有40％以上的人口有患这种疾病的危险。由于包括疟疾寄生虫抗性增加在内的多种因素的综合作用，近年来疟疾感染一直在增加。现在，在许多地区，大多数恶性疟原虫菌株都对常规药物如氯喹具有抗药性。这项研究的目的是比较奎宁和青蒿琥酯治疗恶性疟原虫疟疾的疗效和安全性。方法：这是一项基于医院的前瞻性研究，对35例重度恶性疟原虫疟疾患者进行了随机选择。排除任何一种药物禁忌症的患者，以避免偏倚。标准统计测试适用于定性和定量数据。结果：根据研究终点，接受两种药物治疗的患者的死亡率差异均不显着（p> 0.75），但临床参数如发烧清除时间的差异（p结论）：青蒿琥酯在死亡率方面与奎宁一样好，但青蒿琥酯在发烧清除时间（FCT）和寄生虫清除时间（PCT）方面均优于青蒿琥酯，奎宁比青蒿琥酯的昏迷时间更快，两种药物均无明显副作用，因此青蒿琥酯在重症患者中的治疗效果相当或优于恶性疟疾。

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