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首页> 外文期刊>International Journal of Basic & Clinical Pharmacology >Role of free radical scavengers in oral malignancies treated with radiotherapy
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Role of free radical scavengers in oral malignancies treated with radiotherapy

机译：自由基清除剂在放疗治疗口腔恶性肿瘤中的作用

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Background: Radiotherapy has an important role in treatment of oral cancer, but it causes some deleterious effect on healthy cells. Radiation produces free radicals which cause lipo-peroxidation, alteration of protein, and DNA damage, and eventually cell death. This study is designed to evaluate protective role of antioxidants in oral malignancies treated with radiotherapy. Methods: This study is conducted in patients of oral cancer treated with radiotherapy. Patients were divided into two groups, control (n=7) and test (n=9). Patients in control group treated with radiotherapy alone and in test group were supplemented with oral antioxidants throughout the radiotherapy course. Pre and post radiotherapy levels of MDA, SOD and Glutathione reductase were measured in blood and cancerous tissue in both groups and statistically compared. TNM staging before and after radiotherapy and side effects of radiotherapy were also compared in both groups. Results: On statistical comparison of mean difference values of MDA, SOD & GR of control v/s test group, it was noticed that there was a significant reduction in MDA (p 0.05) in test group in comparison to control group for both blood and tissue levels. TNM status of patients improved significantly after radiotherapy in test group. Comparison of side effects between both groups indicated that there was reduction in side effects in test group after radiotherapy. Conclusion: These findings indicated the protective role of antioxidants against free radicals produced in oral malignancies treated with radiotherapy.
机译：背景：放疗在口腔癌的治疗中起着重要作用，但会对健康细胞产生某些有害作用。辐射产生的自由基会引起脂质过氧化，蛋白质改变和DNA损伤，并最终导致细胞死亡。这项研究旨在评估抗氧化剂在放疗治疗的口腔恶性肿瘤中的保护作用。方法：本研究是在放疗治疗的口腔癌患者中进行的。将患者分为两组，对照组（n = 7）和测试组（n = 9）。对照组中仅接受放射治疗的患者和试验组在整个放射治疗过程中均补充了口服抗氧化剂。两组患者血液和癌组织中放疗前后的MDA，SOD和谷胱甘肽还原酶水平均进行了测量，并进行了统计学比较。两组还比较了放疗前后的TNM分期和放疗的副作用。结果：通过对对照组v / s测试组的MDA，SOD和GR的平均差异值进行统计比较，发现与血液对照组相比，测试组的MDA显着降低（p 0.05）。组织水平。试验组放疗后患者的TNM状态明显改善。两组之间的副作用比较表明，放疗后测试组的副作用有所减少。结论：这些发现表明抗氧化剂对放射治疗的口腔恶性肿瘤产生的自由基具有保护作用。

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