...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International Journal of Basic & Clinical Pharmacology >Pattern of adverse drug reaction to antiepileptic drugs in a tertiary care hospital
【24h】

Pattern of adverse drug reaction to antiepileptic drugs in a tertiary care hospital

机译：三级医院对抗癫痫药的药物不良反应模式

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: Adverse drug reactions (ADRs) are a major cause of morbidity and mortality, and are the leading cause of hospital admission. The overall rate of ADRs is estimated to be 6.5% and 28% of these ADRs are preventable. Antiepileptic drugs (AEDs) are authorized for several therapeutic indications and are highly prescribed. ADRs due to AEDs range from minor maculopapular exanthem (MPE) to severe life-threatening reactions like Drug reaction eosinophilia and systemic symptoms (DRESS) and Stevens-Johnson syndrome (SJS). Objective of the study was to evaluate the pattern of ADRs reported with AEDs in an adverse drug reaction monitoring centre (AMC) of a tertiary care hospital. Methods: Retrospective analysis of the records was done for a period 48 months from January 2013 to December 2016. During this period, all the ADRs caused by AEDs reported to the AMC were included in the study. The study evaluated the pattern of ADRs due to AEDs. The study also assessed the gender-wise distribution, predilection for various systems, causality, severity, and preventability of ADRs. Data was analysed using descriptive statistics. Results: A total of 319 ADRs were reported by spontaneous reporting during the entire study period. Out of the total 319 ADR reports received, antiepileptic drugs related ADRs were 35 (11%). Antiepileptic drugs which caused the ADRs included phenytoin, carbamazepine, clobazam and lorazepam. The most common system affected was dermatological (60%), followed by gastrointestinal system (17.14%), vascular system (11.42%), blood (5.8%), respiratory system (5.8%) and central nervous system (2.9%). Among the dermatological ADRs, SJS accounted for 11 cases of which 10 cases were due to phenytoin and one case was due to carbamazepine. DRESS syndrome due to phenytoin was documented in one case. Conclusions: AEDs are the most commonly prescribed drugs for various indications. Uses of AEDs are accompanied by ADRs which vary from mild rashes and itching to SJS and DRESS/TEN. Post-marketing surveillance of the AEDs is important for compliance, therapeutic efficacy and ultimately safety of the patient.
机译：背景：药物不良反应（ADR）是发病率和死亡率的主要原因，也是住院的主要原因。 ADR的整体比率估计为6.5％，其中28％是可以预防的。抗癫痫药（AED）已获准用于多种治疗适应症，并已开出高处方。 AED引起的ADR范围从轻微的斑丘疹性发烧（MPE）到严重的危及生命的反应，例如药物反应性嗜酸性粒细胞增多和全身症状（DRESS）和史蒂文斯-约翰逊综合征（SJS）。该研究的目的是评估在三级医院的药物不良反应监测中心（AMC）中使用AED报告的ADR模式。方法：从2013年1月至2016年12月对记录进行回顾性分析，为期48个月。在此期间，研究中包括了所有向AMC报告的由AED引起的ADR。该研究评估了由AED引起的ADR模式。该研究还评估了按性别划分的分布，各种系统的偏爱，ADR的因果关系，严重性和可预防性。使用描述性统计数据分析数据。结果：在整个研究期间，通过自发报告共报告了319种ADR。在收到的319份ADR报告中，与抗癫痫药有关的ADR为35（11％）。引起ADR的抗癫痫药包括苯妥英钠，卡马西平，氯巴沙姆和劳拉西m。受影响最普遍的系统是皮肤科（60％），其次是胃肠系统（17.14％），血管系统（11.42％），血液（5.8％），呼吸系统（5.8％）和中枢神经系统（2.9％）。在皮肤病不良反应中，SJS占11例，其中苯妥英钠10例，卡马西平1例。苯妥英钠引起的DRESS综合征有1例记录在案。结论：AED是用于各种适应症的最常用处方药。 AED的使用会伴有ADR，从轻度皮疹和瘙痒到SJS和DRESS / TEN都有所不同。 AED的上市后监视对于患者的依从性，治疗效果以及最终的安全性至关重要。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号