• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International Journal of Basic and Applied Sciences >Determination of the predictive and prognostic values of polymorphism of some cell cycle genes in breast cancer
【24h】

Determination of the predictive and prognostic values of polymorphism of some cell cycle genes in breast cancer

机译：确定某些细胞周期基因多态性在乳腺癌中的预测和预后价值

获取原文
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Aim: To investigate the influence of the polymorphic variants of CCND1 (G870A) and p73 (G4C14- to- A4T14) on the susceptibility to breast cancer development, also, to figure out their diagnostic and prognostic roles. Subjects and Methods : Blood samples were obtained from breast cancer patients and controls. Genotyping of CCND1 and p73 genes were carried out by PCR-RFLP and PCR-CTPP; respectively. Results : In comparison with the control group, CCND1 (G870A) GA and AA genotypes frequencies were significantly higher in breast cancer patients (p=0.035 and p=0.002; respectively), whereas CCND1 (G870A) GG genotype frequency was significantly lower (p< 0.001). The CCND1 GA and AA genotypes significantly increased the risk for developing breast cancer compared with the GG genotype. The CCND1 (GA+AA) genotypes were significantly correlated with disease-free survival (DFS) of breast cancer patients. In comparison with the control group, p73 (G4C14/A4T14) GC/AT and AT/AT genotypes frequencies were significantly higher in breast cancer patients (p=0.013 and p=0.04; respectively), whereas p73 (G4C14/A4T14) GC/GC genotype frequency was significantly lower (p= 0.004). Compared with the GC/GC genotype, the p73 GC/AT and AT/AT genotypes significantly increased the risk for developing breast cancer. Beside being significantly correlated with DFS, p73 [(GC/AT)+ (AT/AT)] genotypes were indirectly correlated with tumor size, tumor pathological grade, patient's clinical stage, number of axillary lymph node involvement and Her2eu expression. Conclusion : The GA and AA genotypes of CCND1 (G870A) polymorphism and the GC/AT and AT/AT genotypes of p73 (G4C14- to- A4T14) polymorphism can be used as diagnostic markers in breast cancer patients. The presence of the CCND1 (G870A) GA and AA genotypes and the GC/AT and AT/AT genotypes of p73 (G4C14- to- A4T14) polymorphism can increase the susceptibility to breast cancer incidence. Both of CCND1 (G870A) and p73 (G4C14- to- A4T14) polymorphisms can be used for prognosis of breast cancer patients.
机译：目的：研究CCND1（G870A）和p73（G4C14-to-A4T14）多态性变异对乳腺癌发展的敏感性，并弄清它们的诊断和预后作用。受试者和方法：血液样本来自乳腺癌患者和对照。通过PCR-RFLP和PCR-CTPP对CCND1和p73基因进行基因分型。分别。结果：与对照组相比，乳腺癌患者的CCND1（G870A）GA和AA基因型频率显着较高（分别为p = 0.035和p = 0.002），而CCND1（G870A）GG基因型频率显着较低（p <0.001）。与GG基因型相比，CCND1 GA和AA基因型显着增加了患乳腺癌的风险。 CCND1（GA + AA）基因型与乳腺癌患者的无病生存期（DFS）显着相关。与对照组相比，乳腺癌患者中p73（G4C14 / A4T14）GC / AT和AT / AT基因型频率显着更高（分别为p = 0.013和p = 0.04），而p73（G4C14 / A4T14）GC / AT GC基因型频率显着降低（p = 0.004）。与GC / GC基因型相比，p73 GC / AT和AT / AT基因型显着增加了患乳腺癌的风险。除与DFS显着相关外，p73 [（GC / AT）+（AT / AT）]基因型还与肿瘤大小，肿瘤病理分级，患者的临床分期，腋窝淋巴结受累数目和Her2 / neu表达间接相关。结论：CCND1（G870A）多态性的GA和AA基因型和p73（G4C14至A4T14）多态性的GC / AT和AT / AT基因型可作为乳腺癌患者的诊断标记。 CCND1（G870A）GA和AA基因型以及p73（G4C14至A4T14）多态性的GC / AT和AT / AT基因型的存在会增加对乳腺癌发病的敏感性。 CCND1（G870A）和p73（G4C14至A4T14）多态性均可用于乳腺癌患者的预后。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号