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首页> 外文期刊>International Journal of Basic Medical Sciences and Pharmacy >HbA1c: Predictor of Dyslipidemia and Atherogenicity in Diabetes Mellitus
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HbA1c: Predictor of Dyslipidemia and Atherogenicity in Diabetes Mellitus

机译：HbA1c：糖尿病血脂异常和致动脉粥样硬化的预测因子

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This study was done to evaluate the diagnostic value of Glycated hemoglobin (HbA1c) in predicting diabetic dyslipidemia and atherogenicity. The study consisted of 70 male patients of type 2 diabetes mellitus of age between 45-50, duration more than 5 years. The patients were classified into two groups depending on their glycated hemoglobin (HbA1c); Good Glycemic Control (GGC) group having HbA1c < 7.0% (n= 35) and Poor Glycemic Control (PGC) group having HbA1c > 7.0% (n= 35). Dyslipidemia was defined as per the National Cholesterol Education Programme (NCEP) Adult Treatment Panel (ATP) III guidelines. Standard tests were used to analyze Fasting blood glucose level (FBSL), Glycated hemoglobin level (HbA1c) and serum Lipid Profile: Triglyceride (TG), Total Cholesterol (TCH), low-density lipoprotein cholesterol (LDL) and high-density lipoprotein cholesterol (HDL). While Atherogenic Index of Plasma (AIP) was calculated by standard formula (base 10 logarithm of the ratio of TG to HDL). Statistical analysis was done by Z test using Microsoft Office Excel 2010. HbA1c showed direct correlation with FBSL, TG, TCH, LDL and AIP while there was inverse correlation with HDL. Statistically significant ?p? values were obtained for FBSL, TG, LDL and AIP. While that for TCH and HDL was not significant. These findings clearly indicate that HbA1c can provide valuable supplementary information about the extent of circulating lipids and AIP besides its primary role in monitoring long-term glycemic control. Thus, HbA1c can be used as a predictor of cardiovascular risk in diabetics.
机译：这项研究旨在评估糖化血红蛋白（HbA1c）在预测糖尿病血脂异常和动脉粥样硬化中的诊断价值。该研究由70位年龄在45至50之间，持续时间超过5年的2型糖尿病男性患者组成。根据患者的糖化血红蛋白（HbA1c）将其分为两组; HbA1c <7.0％（n = 35）的血糖控制良好（GGC）组和HbA1c> 7.0％（n = 35）的血糖控制不良（PGC）组。根据国家胆固醇教育计划（NCEP）成人治疗小组（ATP）III指南定义血脂异常。使用标准测试分析空腹血糖水平（FBSL），糖化血红蛋白水平（HbA1c）和血清脂质谱：甘油三酸酯（TG），总胆固醇（TCH），低密度脂蛋白胆固醇（LDL）和高密度脂蛋白胆固醇（HDL）。通过标准公式（TG与HDL的比率以10为底的对数）计算血浆的动脉粥样化指数（AIP）。使用Microsoft Office Excel 2010通过Z检验进行统计分析。HbA1c显示与FBSL，TG，TCH，LDL和AIP直接相关，而与HDL则呈反相关。具有统计意义的“ p”获得了FBSL，TG，LDL和AIP的值。尽管对于TCH和HDL而言，这并不重要。这些发现清楚地表明，HbA1c除了在监测长期血糖控制中起主要作用外，还可以提供有关循环脂质和AIP程度的有价值的补充信息。因此，HbA1c可以用作糖尿病患者心血管风险的预测指标。

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