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首页> 外文期刊>International Journal of Basic Medical Sciences and Pharmacy >An investigation of the toxic effects of cooked phosphide-residue contaminated cowpea on wistar rats
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An investigation of the toxic effects of cooked phosphide-residue contaminated cowpea on wistar rats

机译：煮熟的磷残留污染的cow豆对wistar大鼠的毒性作用研究

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Pesticide related death is common in Nigeria. Many of these deaths have been identified to occur as result of misuse of these chemicals. For example, it was demonstrated in an earlier study that contamination of cowpea with phosphide residue post-fumigation is capable of considerable hepato-renal damage. The aim of this study is to determine if processing of such contaminated cowpea is capable of such degree of hepatic and renal damage. Eighteen female Wistar rats used for the study were randomly divided into 3 groups and fed cooked phosphide-residue contaminated cowpea for a period of 8 hours. After which blood was collected for the estimation of hepato-renal indices; tissues were also processed for histologic examination. None of the indices (alanine and aspartate amino transferases, alkaline phosphatase, γ-glutamyl transferase, total protein, albumin, globulin, urea, creatinine, uric acid) were significantly different (p>0.05) compared with control, histology result revealed no visible lesion for kidney section although mild infiltration of mononuclear cells were observed for liver sections. The results of this study suggest that processing of phosphide-residue contaminated cowpea is capable of modulating its hepato-nephrotoxic effects.
机译：与农药有关的死亡在尼日利亚很常见。已确定其中许多死亡是由于滥用这些化学品造成的。例如，在较早的研究中证明，熏蒸后磷with残留物污染cow豆会严重损害肝肾。这项研究的目的是确定加工这种被污染的pea豆是否能够对肝脏和肾脏造成这种程度的损害。将用于研究的18只雌性Wistar大鼠随机分为3组，并喂食煮熟的磷化物残留污染的cow豆，持续8小时。之后收集血液以评估肝肾指标;还对组织进行处理以进行组织学检查。指标（丙氨酸和天冬氨酸氨基转移酶，碱性磷酸酶，γ-谷氨酰转移酶，总蛋白，白蛋白，球蛋白，尿素，肌酐，尿酸）与对照组相比均无显着差异（p> 0.05），组织学结果显示无明显变化肾脏切片可见病变，尽管肝脏切片观察到单核细胞轻度浸润。这项研究的结果表明，对磷化物残留物污染的processing豆的加工能够调节其肝肾毒性作用。

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