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首页> 外文期刊>International Journal of Basic & Clinical Pharmacology >Study of effects of antiepileptic therapy on various biochemical and hematological parameters patients suffering of epilepsy
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Study of effects of antiepileptic therapy on various biochemical and hematological parameters patients suffering of epilepsy

机译：抗癫痫治疗对癫痫患者各种生化和血液学参数影响的研究

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Background: Low therapeutic index of established antiepileptic drugs (AEDs) coupled with better understanding of the pathophysiology of seizure has encouraged the development of several novel AEDs. The conventional antiepileptics like phenytoin, phenobarbitone, valproate and carbamazepine and newer antiepileptics like levetiracetam, lamotrigine and topiramate etc. are used for epilepsy. AEDs induce potentially toxic effects over a period of time which remains undetermined over very long time. Earlier studies in this regard, states uneven results about biochemical (i.e. blood sugar level, lipid profile) and hematological (Hb%, blood cell count etc.) toxicity of AEDs. Aims: To unveil the toxic effects of AEDs when given singly or as combinations. Methods: Adult epileptics of either sex taking antiepileptic monotherapy or combination therapy for ≥ six months were enrolled. Biochemical and hematological parameters studied were compared with their age and sex matched controls, baseline and amongst groups. Statistical Analysis Used: Student's 't'-test & One way ANOVA followed by posthoc Tukey HSD test for pair wise comparison; p Results: Conventional antiepileptic combination therapy was found more toxic; p 0.05). Monotherapy and conventional combination therapy caused significant reduction in platelet count (p Conclusions: Monotherapy found less toxic with no significant effects on lipid profile, Hb%, RBC count and O2 carrying capacity and less impact on platelets while combination therapy did not show any advantage over monotherapy and its use must be reserved only for refractory cases.
机译：背景：既有的抗癫痫药（AED）的治疗指数较低，加上对癫痫发作的病理生理学的更好理解，鼓励了几种新型AED的开发。用于癫痫的常规抗癫痫药如苯妥英，苯巴比妥，丙戊酸盐和卡马西平以及较新的抗癫痫药如左乙拉西坦，拉莫三嗪和托吡酯等。 AED会在一段时间内诱发潜在的毒性作用，但在很长一段时间内仍无法确定。在这方面的较早研究表明，有关AED的生化（即血糖水平，脂质分布）和血液学（Hb％，血细胞计数等）毒性的结果不一致。目的：揭示单独或组合使用时AED的毒性作用。方法：入选了接受抗癫痫单药治疗或联合治疗≥6个月的成人性癫痫病患者。将研究的生化和血液学参数与其年龄和性别相匹配的对照组，基线以及各组之间进行比较。使用的统计分析：学生't'检验和单向方差分析，再进行事后Tukey HSD检验，以进行成对比较; p结果：常规抗癫痫药联合治疗被发现毒性更大; p 0.05）。单一疗法和常规联合疗法导致血小板计数显着降低（p结论：单一疗法发现毒性较小，对血脂，Hb％，RBC计数和O2携带量无显着影响，对血小板的影响较小，而联合疗法未显示任何优势。单一疗法及其使用必须仅保留于难治性病例。

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