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首页> 外文期刊>International Journal of Biomedical and Advance Research >Electrophysiological changes in sensorimotor nerves in diabetes mellitus & usefulness of nerve conduction studies for early diagnosis of diabetic neuropathy
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Electrophysiological changes in sensorimotor nerves in diabetes mellitus & usefulness of nerve conduction studies for early diagnosis of diabetic neuropathy

机译：糖尿病感觉运动神经的电生理变化和神经传导研究对糖尿病性神经病的早期诊断的实用性

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Background: Diabetes Mellitus(DM) a metabolic disorder is the most common cause of peripheral neuropathy. As a result of long term hyperglycemia there is damage to nerves that develops diabetic neuropathy. Nerve conduction studies(NCS) are commonly employed to detect the neuropathy. The present study was undertaken to find out the utility of NCS as an early indicator of neuropathy in diabetic patients. Materials & methods : Study was carried out in 50 diagnosed DM patients attending outpatient department(OPD) in Medicine, Civil Hospital, Ahmedabad. 25 age matched non-diabetic & healthy males were selected for control group. Diabetic patients having FBS110 mg/dL were selected for studies with duration of DM for more than 5 years. Their glycosylated Hb(HbA1c) levels were measured for glycaemic control. NCS was performed by standard Nerve Conduction Velocity-Electromyography(NCS-EMG) equipment at Institute of Spine, Civil Hospital Campus, Ahmedabad. Nerve conduction parameters like compound muscle action potential(CMAP), sensory nerve action potential(SNAP), nerve conduction velocity(NCV) & distal latency(DL) were studied. Results: In our study there is increase in DL of peroneal & sural nerves in group B subjects. NCV of peroneal, sural, median sensory & ulnar sensory nerves decreases in group B subjects. SNAP of median sensory, sural nerves is decreased in group B & SNAP of sural nerve is decreased in group A also. Datas were summarized with Pearson?? Correlation test, p-value 0.05 were considered as significant (S), 0.001 as highly significant (HS) & 0.05 as not significant (NS). Conclusion: As DM progress further, it increases risk of neuronal involvement which can be accelerated by poor glycaemic control. Our result indicates demyelinating type of neuropathy with some changes of axonopathy. Therefore NCS is done for early detection of neuropathy in DM patients. Key words: Diabetes Mellitus (DM), hyperglycaemia, Nerve conduction studies (NCS), Diabetic neuropathy (DN)
机译：背景：糖尿病（DM）是一种代谢紊乱，是周围神经病变的最常见原因。长期高血糖症的结果是对神经的损害，发展为糖尿病性神经病。神经传导研究（NCS）通常用于检测神经病变。进行本研究以发现NCS作为糖尿病患者神经病变的早期指标的用途。材料与方法：研究对象是50位就诊于艾哈迈达巴德市民政医院内科门诊（OPD）的DM患者。选择25名年龄匹配的非糖尿病和健康男性作为对照组。选择FBS> 110 mg / dL的糖尿病患者进行DM持续时间超过5年的研究。测量其糖基化的Hb（HbA1c）水平以进行血糖控制。 NCS由艾哈迈达巴德市民用医院校园脊柱研究所的标准神经传导速度电描记仪（NCS-EMG）设备执行。研究了复合肌动作电位（CMAP），感觉神经动作电位（SNAP），神经传导速度（NCV）和远端潜伏期（DL）等神经传导参数。结果：在我们的研究中，B组受试者腓骨和腓肠神经的DL升高。 B组受试者腓肠，腓肠，正中感觉神经和尺骨感觉神经的NCV降低。 B组中位感觉，腓肠神经的SNAP降低，A组中腓肠神经的SNAP也降低。数据归纳为Pearson ??相关性检验，p值<0.05被认为是显着（S），<0.001被认为是高度显着（HS），> 0.05被认为是不显着（NS）。结论：随着DM的进一步发展，它会增加神经元受累的风险，而血糖控制不佳可能会加速这种风险。我们的结果表明神经病变的脱髓鞘类型伴有轴突病变的某些变化。因此，NCS用于DM患者的神经病变的早期检测。关键词：糖尿病（DM），高血糖症，神经传导研究（NCS），糖尿病性神经病变（DN）

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