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首页> 外文期刊>International Journal of Biochemistry Research & Review >Relevance of Chrysanthellum americanum (L.) Vatke Extracts in Rat Liver Protection
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Relevance of Chrysanthellum americanum (L.) Vatke Extracts in Rat Liver Protection

机译：美洲菊花提取物在大鼠肝保护中的相关性

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Aims: To assess the relevance of Chrysanthellum americanum (L.) Vatke extracts in rat liver protection. Place and Duration of Study: Laboratory of Biochemistry and Applied Chemistry (LABIOCA), also in Laboratory of Department of Medicine and Traditional Pharmacopoeia (MEPHATRA-PH) of Institute for Research in Health Sciences (IRSS/CNRST) of Burkina Faso between July 2014 and August 2015. Study Design: Polyphenolic extract of Chrysanthellum americanum - in vivo liver protection- in vivo liver intoxication- liver necrosis parameters analysis, histopathology analysis, in vivo and in vitro antioxidant assay. Background: Chrysanthellum americanum L. (Vatke) is a medicinal plant well known for its flavonoids and saponins richness, but also for its strong antioxidant potential and use traditionally for liver disease treatment. Methodology: In vivo , anti hepatotoxicity effects of Chrysanthellum americanum was evaluated using CClsub4/sub as hepatotoxic agent. Also, acute toxicities were determined using standards methods, serum parameters of liver injury using Cypress Diagnostics kits and histopathology analysis using Mayer's haematoxylin- eosin-phloxine coloration method. For in vitro tests, malondialdehyde and thiobarbituric acid method were used in lipid peroxidation assessment and the ABTS method in Trolox Equivalent Antioxidant Capacity assessing. Results: Result showed that the crude extract of C. americericum has a very low oral toxicity but, in intraperitoneal route this extract presented a high toxicity (LD50= 175 mg / kg of body weight). Histopathology micrograph indicated reduction in number of necrotic cells induced by CClsub4/sub. This beneficial action was confirmed by reduction in serum transaminases and malondialdehyde (22.68 ± 0.68 mmol MDA/ g of liver weight). In vitro antioxidant capacities, this plant extract presented a result of 35.01 ± 0.26 % and 42.01 ± 0.26 mg TE/ g respectively in LPO and TEAC. Conclusion: Given our results, our research confirms that Chrysanthellum americanum extracts have in vivo physiological impact and benefits in traditional medicine for specific care of liver diseases.
机译：目的：评估美国菊花（V. Vatke）提取物在大鼠肝脏保护中的相关性。研究的地点和持续时间：2014年7月至2014年7月之间，还位于布基纳法索卫生科学研究所（IRSS / CNRST）的医学和传统药典系（MEPHATRA-PH）的生物化学与应用化学实验室（LABIOCA） 2015年8月。研究设计：美洲菊花的多酚提取物-体内肝脏保护-体内肝脏中毒-肝脏坏死参数分析，组织病理学分析，体内和体外抗氧化剂测定。背景：美洲菊花（Vatke）是一种药用植物，以其类黄酮和皂苷丰富而著称，还具有很强的抗氧化潜力，并且传统上用于肝病治疗。方法：在体内，使用CCl 4 作为肝毒性剂评估了美洲菊花的抗肝毒性作用。此外，使用标准方法测定急性毒性，使用Cypress Diagnostics试剂盒测定肝脏损伤的血清参数，并使用Mayer's苏木精-伊红-福禄辛显色法进行组织病理学分析。对于体外测试，丙二醛和硫代巴比妥酸法用于脂质过氧化评估，ABTS法用于Trolox等效抗氧化剂容量评估。结果：结果表明，美国隐孢子虫的粗提物具有极低的口服毒性，但在腹膜内途径中，该提呈高毒性（LD50 = 175 mg / kg体重）。组织病理学显微照片表明，CCl 4 诱导的坏死细胞数量减少。通过降低血清转氨酶和丙二醛（22.68±0.68 mmol MDA /克肝重），证实了这一有益作用。在体外抗氧化能力方面，该植物提取物在LPO和TEAC中的结果分别为35.01±0.26％和42.01±0.26 mg TE / g。结论：根据我们的研究结果，我们的研究证实，美国菊花提取物在传统医学中对肝脏疾病的特殊护理具有体内生理影响和益处。

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