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首页> 外文期刊>International Journal of Biochemistry Research & Review >Anti-inflammatory Effect of Entandrophragma angolense Bark Extracts on Acute Edema of the Rat's Paw Induced by Carrageenan
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Anti-inflammatory Effect of Entandrophragma angolense Bark Extracts on Acute Edema of the Rat's Paw Induced by Carrageenan

机译：鹿茸树皮提取物对角叉菜胶诱导的大鼠足爪急性水肿的抗炎作用

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Aims: Our work consisted to evaluate the anti-inflammatory activity of the bark of Entandrophragma angolense in the laboratory. Methods: The experiments were carried out on the model of acute edema of the rat's paw induced by carrageenan and the determination of C-reactive protein. The aqueous and ethanolic extracts, at doses of 100 and 200 mg/kg body weight were administered orally to the rats. The extracts were administered an hour before induction of acute inflammation with 1% carrageenan. The results obtained were compared to those of Diclofenac Sodium and those of physiological control. Results: After administration of the distilled water, the carrageenan induced edema which increased gradually with a maximum of 38.41% after five hours of observation. The administration of Diclofenac Sodium at dose of 10 mg/kg b.wt as well as aqueous and ethanolic extracts of E. angolense significantly prevented the increase in the diameter of the rat's paw. From the 1st to the 4th hour, the aqueous extract at dose of 200 mg/kg b.wt respectively shows a percentage of inhibition similar to that of Diclofenac Sodium. Then, the administration of the extracts and Diclofenac Sodium decreased the concentration of CRP induced by the injection of carrageenan compared to the control. Conclusion: E. angolense has a mechanism of anti-inflammatory action similar to that of non-steroidal anti-inflammatory drugs which could be attributed to its phytochemical constituents.
机译：目的：我们的工作包括在实验室中评估安氏钩En（Entandrophragma angolense）树皮的抗炎活性。方法：采用角叉菜胶诱导大鼠足爪急性水肿的模型，并测定C反应蛋白。将100和200mg / kg体重的剂量的水和乙醇提取物口服给予大鼠。在用1％角叉菜胶诱导急性炎症之前一小时给予提取物。将获得的结果与双氯芬酸钠和生理学对照进行比较。结果：给予蒸馏水后，角叉菜胶引起的水肿在观察五个小时后逐渐增加，最大为38.41％。给予剂量为10 mg / kg b.wt的双氯芬酸钠以及Angolense的水提取物和乙醇提取物可显着阻止大鼠爪子直径的增加。从第1至第4小时，以200 mg / kg b.wt的剂量的水提取物分别显示出与双氯芬酸钠相似的抑制百分比。然后，与对照相比，提取物和双氯芬酸钠的施用降低了通过注射角叉菜胶而诱导的CRP浓度。结论：Angolense具有与非甾体类抗炎药相似的抗炎作用机制，这可能归因于其植物化学成分。

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