• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International Journal of Basic and Applied Sciences >Pharmacokinetics and tissue residue of toltrazuril in broiler chickens
【24h】

Pharmacokinetics and tissue residue of toltrazuril in broiler chickens

机译：肉仔鸡中托曲脲的药代动力学和组织残留

获取原文
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The pharmacokinetics and tissue residue of toltrazuril (Baycox ? , Bayer Animal Health) were investigated in broiler chickens after repeated oral administrations of 7 mg/kg b.wt once daily for two consecutive days. Chickens were subjected to clinical diagnosis to ensure that each one is free from any Eimeria was received a standard broiler feed free from any medications. The results revealed that following repeated oral administration; toltrazuril peaked in blood with [C max ] of 6.56 and 6.70 μg/ml at [T max ] of 2.56 and 2.52 hours and the elimination half-life [t 1/2β ] of 14.92 and 16.19 hours and the mean residence times (MRT) were 21.33 and 23.14 hours after first and second doses, respectively. The tissue level concentrations were highest in the kidney and decreased in the following order: liver > lung > heart > muscle > skin and fat. No toltrazuril residues were detected in tissues and plasma after 8 days.
机译：在连续两天每天重复一次口服7 mg / kg b.wt的肉鸡后，研究了toltrazuril（Baycox®，Bayer Animal Health）的药代动力学和组织残留。鸡接受了临床诊断，以确保每只鸡都没有艾美叶虫，并且接受了不含任何药物的标准肉鸡饲料。结果表明，经反复口服给药;托曲唑的血峰达到峰值[C max]为6.56和6.70μg/ ml，[T max]为2.56和2.52小时，消除半衰期[t 1 /2β]为14.92和16.19小时，平均停留时间）分别在第一次和第二次给药后21.33和23.14小时。肾脏中的组织水平浓度最高，并按以下顺序降低：肝脏>肺>心脏>肌肉>皮肤和脂肪。 8天后在组织和血浆中未检测到托拉西利残留。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号