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首页> 外文期刊>International Journal of Basic and Applied Sciences >Comparative Study of Nutritional Values of Edible Viscera Mediterranean Mollusks Gastropods hexaplex trunculus and bolinus brandaris. Hypobranchial glands inhibit Human Glioblastoma U87 Tumor Cells Adhesion and Proliferation
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Comparative Study of Nutritional Values of Edible Viscera Mediterranean Mollusks Gastropods hexaplex trunculus and bolinus brandaris. Hypobranchial glands inhibit Human Glioblastoma U87 Tumor Cells Adhesion and Proliferation

机译：食用内脏地中海软体动物腹足类六倍体轮虫和野菜白兰地的营养价值比较研究。下支气管腺抑制人胶质母细胞瘤U87肿瘤细胞的粘附和增殖

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This study aims first to identify nutritionals values of edible mix Muscle Hypobranchial Gland MHG, fresh and cooked extract from internal organs of two gastropods mollusks Hexaplex trunculus HT and Bolinus brandaris BB males and females. Second, to characterize and evaluate the role of hypobranchial glands extract HBGE of these mollusks gastropods on adhesion and cell proliferation of human glioblastoma tumor cells U87. Biochemical analyzes show that fresh MHG, HT and BB are rich in Water 82.52% in HT males, 79.23% in HT females. They are rich in Proteins 12.79 % in BB females to 10.30% in HT females) and in Energy value 79.14 kcal in BB females to 69.48kcal in HT males. They contain fewer carbohydrates 6.27% in BB males to 5.40% in HT males, less total ash 1.52% in HT females to 1.11% in HT males and less lipids 2.55% in HT females to 0.74% in BB males. Further, HBGE of HT inhibited U87 cell adhesion to fibrinogen at 15 mg/ml. This inhibition was accelerated at 20 mg/ml without exceeding 50% of inhibition. HBGE of BB reduced glioblastoma cells adhesion upon to 5 mg/ml with IC50 values of 9 mg/ml for male and 20 mg/ml for female. U87 cells treated with HBGE HT and BB decreased significantly cell proliferation by 50% and 70% respectively. Our results lead us to encourage the use of these marine snails, source of protein and high energy values. Moreover, HBGE may have the potential to serve as a template for future anticancer-drug development. Keywords : Mix Muscle- Hypobranchial Gland, Hexaplex Trunculus, Bolinus Brandaris, Nutritional Values, Glioblastoma U87 Cells, Cell Adhesion and Proliferation.
机译：这项研究首先旨在确定可食用混合物肌肉下支气管MHG的营养价值，这是两种腹足类软体动物六面体HT和Bolinus brandaris BB雄性和雌性内脏的新鲜和煮熟的提取物。其次，表征和评价这些软体动物腹足动物的支气管腺提取物HBGE对人胶质母细胞瘤肿瘤细胞U87的粘附和细胞增殖的作用。生化分析表明，新鲜的MHG，HT和BB男性HT中的水含量高达82.52％，女性HT中的79.23％。它们在BB雌性中的蛋白质含量为12.79％，在HT雌性中的蛋白质含量为10.30％），BB雌性中的能量值为79.14 kcal，在HT雄性中的能量值为79.14 kcal。它们在BB雄性中的碳水化合物含量为6.27％，在HT雄性中的含量为5.40％，在HT雌性中的总灰分为1.52％，在HT雄性中的含量为1.11％，在HT雌性中的脂质为2.55％，BB雄性的含量为0.74％。此外，HT的HBGE以15mg / ml抑制U87细胞对血纤蛋白原的粘附。该抑制作用以20 mg / ml的速度被加速而没有超过50％的抑制作用。 BB的HBGE将胶质母细胞瘤细胞的粘附力降低至5 mg / ml，男性的IC50值为9 mg / ml，女性的IC50值为20 mg / ml。 HBGE HT和BB处理的U87细胞分别显着降低了50％和70％的细胞增殖。我们的结果促使我们鼓励使用这些海洋蜗牛，蛋白质来源和高能量价值。此外，HBGE可能有潜力作为未来抗癌药物开发的模板。关键词：混合肌下支气管，六边形花梗，Bolinus Brandaris，营养价值，胶质母细胞瘤U87细胞，细胞黏附和增殖。

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