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首页> 外文期刊>International Journal of Biochemistry Research & Review >Functional and Histomorphological Assessments of Liver and Kidney in Matured Female Albino Wistar Rats Following Ingestion of Citrullus lanatus Seed Extracts
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Functional and Histomorphological Assessments of Liver and Kidney in Matured Female Albino Wistar Rats Following Ingestion of Citrullus lanatus Seed Extracts

机译：摄入柑桔种子提取物的成年雌性白化Wistar大鼠肝脏和肾脏的功能和组织形态学评估

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摘要

Oil from different seeds in fruits has been exploited for nutritional and health benefits ranging from provision of essential nutrients for cellular metabolic processes to being an alternative route to the orthodox drugs in the quest for a better living. However, adverse consequences following consumption of this seed oils on both the liver and kidney are not well known. The present study was carried out to assess the integrity of the liver and kidney following the administration of different doses of Citrullus lanatus seed extracts (oil) to mature female albino Wistar rats. Twenty - four female albino Wistar rats weighing between 179 g – 257 g were randomly divided into four groups of six animals per group. Animals in group 1(control group) received normal rat chow placebo. The experimental groups 2, 3, and 4 received 932.0 mg, 1864.0 mg and 2796.0 mg seed oil extract / kg body weight in 0.2, 0.4 and 0.6 ml respectively for twenty-one (21) days by oral gavaging. The effects of treatment on the integrity of the liver and kidney were assessed by measuring the activities of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) for liver and Nasup+/sup, Ksup+/sup, Clsup-/sup, HCOsub3/sub and Creatinine for kidney as well as the histomorphology of the liver and kidney for possible distortions. The results showed a dose-dependent decrease that was only significant (p0.05) in group 4 relative to the control group for ALT, while both AST and ALP showed non-significant (p0.05) changes. Furthermore, non-significant changes were recorded for Nasup+/sup, Ksup+/sup, Clsup-/sup, HCOsub3/sub and Creatinine. Histomorphologically, the liver and kidney integrity were not altered except for fatty infiltration of group 4 hepatocytes relative to control group and hyperchromasia of group 4 kidney relative to control. Generally, this study showed that Citrullus lanatus seed oil consumption results are of great advantage to liver and kidney tissues when consumed.
机译：从水果中的不同种子中提取的油已被用于营养和健康方面，从提供细胞代谢过程所需的营养素到为寻求更好的生活而成为正统药物的替代途径。然而，食用这种籽油后在肝脏和肾脏上产生的不良后果尚不为人所知。进行本研究以评估对成年雌性白化病Wistar大鼠施用不同剂量的柑桔籽提取物（油）后肝脏和肾脏的完整性。将二十四只体重在179 g – 257 g之间的白化Wistar雌性大鼠随机分为四组，每组六只动物。第1组（对照组）的动物接受了正常的大鼠食物安慰剂。实验组2、3和4通过口服灌胃分别在0.2、0.4和0.6 ml中接受932.0 mg，1864.0 mg和2796.0 mg / kg体重的种子油提取物/ kg体重，持续二十（21）天。通过测量血清丙氨酸氨基转移酶（ALT），天冬氨酸氨基转移酶（AST）和碱性磷酸酶（ALP）对肝脏和Na + 的活性来评估治疗对肝脏和肾脏完整性的影响，K + ，Cl -，HCO 3 和肌酐对肾脏的影响以及肝脏和肾脏的组织形态学可能的畸变。结果显示，与对照组相比，第4组的剂量依赖性降低仅显着（p <0.05），而AST和ALP均无显着性改变（p> 0.05）。此外，记录了Na + ，K + ，Cl -，HCO 3 和肌酐的无明显变化。 。在组织形态学上，除了相对于对照组的第4组肝细胞的脂肪浸润和相对于对照组的第4组肾脏的增色，肝脏和肾脏的完整性没有改变。一般而言，这项研究表明食用柑桔籽油的结果对食用肝和肾组织有很大的好处。

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