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首页> 外文期刊>International Journal of Biochemistry Research & Review >Effect of Plant Spices (Thymus vulgaris,Murraya koenigii, Ocimum gratissimum,Piper guineense) on Hemoglobin Glycation,Selected Enzymes and Red Blood Cell Indicesin Alloxan-induced Diabetic Rats
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Effect of Plant Spices (Thymus vulgaris,Murraya koenigii, Ocimum gratissimum,Piper guineense) on Hemoglobin Glycation,Selected Enzymes and Red Blood Cell Indicesin Alloxan-induced Diabetic Rats

机译：植物香料（百里香，墨兰，罗汉果，Piper guineense）对四氧嘧啶致糖尿病大鼠血红蛋白糖化，某些酶和红细胞指标的影响

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Aim: The aim of this study was to determine the effect of plant spices (Thymus vulgaris, Murraya koenigii, Ocimum gratissimum and Piper guineense) on hemoglobin glycation (HbA1c), lactate dehydrogenase (LDH), glucose-6-phosphate dehydrogenase (G6PD) and red blood cell (RBC) indices in alloxan- induced diabetic rats. Study Design: The animals were grouped into six of 5 rats each. Groups II, III, IV, V and VI were induced diabetes by intraperitoneal injection of alloxan monohydrate with a dose of 170mg/kg body weight. Group I was the control, group II diabetic control and group III to VI were the experimental group. Crude aqueous extracts (500mg/kg body weight) of the spices were orally administered to the rats. Methodology: Blood samples were collected by cardiac puncture after fasting overnight and standard methods were used for the extraction of spices and, determination of biochemical and hematological parameters.Place and Duration of Study: The study was carried out at Enugu State University Teaching Hospital from September 2012 to January 2013.Result: The result showed that glycated hemoglobin, fasting blood sugar and lactate dehydrogenase decreased significantly (P<0.05) while, glucose-6-phosphate dehydrogenase increased significantly (P<0.05) compared to diabetic control group but, no significant difference (P<0.05) was observed compared to normal control group. There were no significant differences (P<0.05) in red blood cell indices compared to diabetic control and normal control. Conclusion: This study suggested that the spices extracts can be used to control diabetes and prevent its complications on antioxidant enzymes.
机译：目的：本研究的目的是确定植物香料（百里香，百里香，香茅和胡椒）对血红蛋白糖化（HbA1c），乳酸脱氢酶（LDH），葡萄糖-6-磷酸脱氢酶（G6PD）的影响。和四氧嘧啶致糖尿病大鼠的红细胞（RBC）指数。研究设计：将动物分成5只大鼠中的6只。通过腹膜内注射剂量为170mg / kg体重的四氧嘧啶一水合物诱导第二，第三，第四，第五和第六组糖尿病。第一组为对照组，第二组为糖尿病对照组，第三至第六组为实验组。对大鼠口服粗制的香料水提取物（500mg / kg体重）。方法：禁食过夜后，通过心脏穿刺收集血液样本，并使用标准方法提取香料，测定生化和血液学参数。研究地点和持续时间：该研究于9月在Enugu州立大学教学医院进行。 2012年至2013年1月。结果：与糖尿病对照组相比，糖化血红蛋白，空腹血糖和乳酸脱氢酶显着降低（P <0.05），而6磷酸葡萄糖-葡萄糖脱氢酶显着提高（P <0.05），但无与正常对照组比较，差异有统计学意义（P <0.05）。与糖尿病对照组和正常对照组相比，红细胞指数没有显着差异（P <0.05）。结论：这项研究表明，香料提取物可用于控制糖尿病并预防其抗氧化酶并发症。

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