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首页> 外文期刊>International Journal of Biochemistry, Biophysics & Molecular Biology >Molecular Screening of Glucose-6-Phosphate Dehydrogenase Among Deficient Children Aged 0-5 Years with iPlasmodium falciparum/i Malaria in Katsina State, Nigeria
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Molecular Screening of Glucose-6-Phosphate Dehydrogenase Among Deficient Children Aged 0-5 Years with iPlasmodium falciparum/i Malaria in Katsina State, Nigeria

机译：在尼日利亚卡特西纳州的恶性疟原虫疟疾0至5岁的0-5岁贫困儿童中进行葡萄糖-6-磷酸脱氢酶的分子筛选

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G6PD deficiency is one of the most common human enzyme deficiencies in the world. It is particularly common in populations living in malaria-endemic areas. The aim of this study is to molecularly screen G6PD enzyme among deficient children (aged 0-5 years) with iPlasmodium falciparum/i malaria in Katsina State, North-western Nigeria, and a region with no any molecular information on G6PD enzyme. A total of 200 blood samples were collected from children with iPlasmodium falciparum/i malaria attending six selected hospitals located across the three senatorial zones of the state from March 2015 to May 2015. G6PD deficiency was detected qualitatively using G6PD screening test. Polymerase Chain Reaction (PCR) of 7 samples (6 deficient and 1 control) shows the presence of G202A mutation in all the samples. The nucleotides sequence obtained from sequencing reaction of one deficient and one control samples are 97% homologous to other G6PD genes of different strains. This study has indicated a high prevalence of G6PD deficiency among the study population. Based on the results obtained, there is a need for the routine screening of children for G6PD deficiency in our environment and training of paediatricians in order to avoid cases of drug-induced anaemia, particularly in the treatment of malaria.
机译：G6PD缺乏症是世界上最常见的人类酶缺乏症之一。这在疟疾流行地区的居民中尤为普遍。这项研究的目的是在尼日利亚西北部的Katsina州和一个没有任何分子信息的地区，对患有疟原虫的疟原虫（0-5岁）的缺陷儿童（0-5岁）进行分子筛查G6PD酶。 G6PD酶。从2015年3月至2015年5月，在该州三个参议院地区的六所选定医院中，从恶性疟原虫疟疾儿童中总共采集了200份血液样本。使用G6PD筛查测试定性检测了G6PD缺乏症。 7个样品（6个缺陷和1个对照）的聚合酶链反应（PCR）显示，所有样品中均存在G202A突变。从一种缺陷和一个对照样品的测序反应获得的核苷酸序列与不同菌株的其他G6PD基因同源性为97％。这项研究表明研究人群中G6PD缺乏症的患病率很高。根据获得的结果，有必要在我们的环境中对儿童进行G6PD缺乏症的常规筛查，并培训儿科医生，以避免药物引起的贫血，特别是在治疗疟疾方面。

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