• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International Journal of Clinical and Experimental Pathology >FoxM1 influences embryo implantation and is regulated by 17 beta-estradiol and progesterone in mouse uteri and endometrium cells
【24h】

FoxM1 influences embryo implantation and is regulated by 17 beta-estradiol and progesterone in mouse uteri and endometrium cells

机译：FoxM1影响胚胎着床并受小鼠子宫和子宫内膜细胞中17β-雌二醇和孕酮的调节

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

To be a successful implantation, endometrial receptivity should be established. Forkhead box M1 (FoxM1) is described as a major oncogenic transcription factor in tumor initiation, promotion, and progression. FoxM1 regulates the expression of lots of targeted genes important to cell differentiation, proliferation and apoptosis; cell-cycle progression; and tumor angiogenesis, migration, invasion, and metastasis. According to these functions, we believe that FoxM1 should also play an essential role in embryo implantation. To test our hypothesis, we observed the expression and distribution of FoxM1 during the early pregnancy of mouse. Then, we used Immunohistochemistry to examine the expression of FoxM1 induced by E2 and/or P4 in the ovariectomized mouse uterus and human endometrium cells. This study further investigated whether FoxM1 was an important factor in the implantation. Our results showed that FoxM1 expressed in the mouse uterus during early pregnancy (Day 1 to 5). The expression of FoxM1 gradually increased along pregnancy process; FoxM1 expression could be increased by E2. On the contrary, FoxM1 expression could be decreased by P4 and E2 plus P4. We also detected the proliferation of human endometrium cells. We found that E2 might promote cells proliferation, while P4 and E2 plus P4 inhibited cells proliferation; Inhibiting FoxM1 could interfere the embryo implantation of mouse. Amplification or inhibiting of FoxM1 in JAR cells can increase or decrease the adhesion rate to Rl95-2 and HEC-1A cells separately. Our data indicate that FoxM1 might play an important role during the process of mouse embryo implantation.
机译：为了成功植入，应建立子宫内膜的接受性。前叉箱M1（FoxM1）被描述为肿瘤起始，促进和发展过程中的主要致癌转录因子。 FoxM1调节许多对细胞分化，增殖和凋亡重要的靶基因的表达;细胞周期进程;以及肿瘤血管生成，迁移，侵袭和转移。根据这些功能，我们认为FoxM1在胚胎植入中也应起重要作用。为了检验我们的假设，我们观察了小鼠早期妊娠期间FoxM1的表达和分布。然后，我们使用免疫组织化学检查了由E2和/或P4诱导的卵巢切除的小鼠子宫和人子宫内膜细胞中FoxM1的表达。这项研究进一步调查了FoxM1是否是植入的重要因素。我们的结果表明，FoxM1在妊娠早期（第1至5天）在小鼠子宫中表达。 FoxM1的表达随着妊娠过程逐渐增加。 FoxM1的表达可以通过E2增加。相反，FoxM1的表达可以被P4和E2加P4降低。我们还检测了人子宫内膜细胞的增殖。我们发现E2可能促进细胞增殖，而P4和E2加P4抑制细胞增殖。抑制FoxM1可能会干扰小鼠的胚胎植入。在JAR细胞中扩增或抑制FoxM1可以分别增加或减少对Rl95-2和HEC-1A细胞的粘附率。我们的数据表明FoxM1可能在小鼠胚胎植入过程中起重要作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号