• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International Journal of Biomedical Science >Effect of bizhongxiao decotion (BZXD) on some cytokines in plasma of rats with CⅡ-induced rheumatoid arthritis
【24h】

Effect of bizhongxiao decotion (BZXD) on some cytokines in plasma of rats with CⅡ-induced rheumatoid arthritis

机译：痹中消汤对CⅡ类风湿性关节炎大鼠血浆某些细胞因子的影响

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objective: To investigate the influence of bizhongxiao decoction(BZXD) which is a Traditional Chinese medicine for RA including, on the plasma TNF-α and IL-1β in rats with CⅡ-induced arthritis (CIA) and explore the protective mechanism of BZXD in the treatment of rheumatoid arthritis . Methods: 75 SD rats were divided into four groups randomly. Normal control group (n=5) not be treated any more. The CIA rat was established by subcutaneous injection with bovine Ⅱ collagen(BⅡC) and complete Freund,s adjuvant(CFA) after 7d breeding. The CIA rats were divided into the CIA group(n=16)、BZXD group (n=29) treated with BZXD and the MTX group(n=25) treated with methotrexate. All rats were killed after various intervals(25,30,35,40,or 45d). At the end of each time interval, we collected the blood of each rat. To detect TNF-αand IL-1βin plasma with radio-immunity kit. Results: BⅡC and CFA can be used to copying CIA model. The incidence of arthritis was 88%. The plasma TNF-αand IL-1βlevels of CIA group, BZXD group and MTX group were notably higher than those of normal control group(p<0.05), moreover, the CIA group was higher than those of the MTX group and BZXD group at various interval (p<0.01). TNF-αand IL-1βrose step by step in CIA group but decreased in BZXD group and MTX group gradually. Moreover, in BZXD group were lower than those in MTX group (p<0.05). Conclusion: TNF-αand IL-1βplay a very important role in the formation and development of RA. BZXD can notably decrease the plasma TNF-αand IL-1βlevels, which was better than MTX.
机译：目的：探讨RA中药必中消汤对CⅡ诱导性关节炎（CIA）大鼠血浆TNF-α和IL-1β的影响，并探讨其保护机制。类风湿关节炎的治疗。方法：75只SD大鼠随机分为四组。正常对照组（n = 5）不再治疗。皮下注射牛Ⅱ型胶原（BⅡC）和完全弗氏佐剂（CFA）7d后，建立CIA大鼠。将CIA大鼠分为CIA组（n = 16），BZXD组（n = 29），BZXD治疗组和MTX组（n = 25），甲氨蝶呤治疗。在不同间隔（25、30、35、40或45天）处死所有大鼠。在每个时间间隔结束时，我们收集了每只大鼠的血液。用放射免疫试剂盒检测血浆中的TNF-α和IL-1β。结果：BⅡC和CFA可用于复制CIA模型。关节炎的发生率为88％。 CIA组，BZXD组和MTX组的血浆TNF-α和IL-1β水平明显高于正常对照组（p <0.05），此外，CIA组在各方面均高于MTX组和BZXD组时间间隔（p <0.01）。 CIA组TNF-α和IL-1β逐渐升高，而BZXD组和MTX组逐渐降低。此外，BZXD组低于MTX组（p <0.05）。结论：TNF-α和IL-1β在RA的形成和发展中起着非常重要的作用。 BZXD可明显降低血浆TNF-α和IL-1β水平，优于MTX。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号