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首页> 外文期刊>International Journal of Clinical and Experimental Pathology >Epithelioid trophoblastic tumor after induced abortion with previous broad choriocarcinoma: a case report and review of literature
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Epithelioid trophoblastic tumor after induced abortion with previous broad choriocarcinoma: a case report and review of literature

机译：先前广泛的绒毛膜上皮癌人工流产后的上皮样滋养细胞肿瘤：一例报道并文献复习

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Epithelioid trophoblastic tumor (ETT) is a rare trophoblastic tumor originating from chorionic-type intermediate trophoblasts (ITs). It is usually associated with a prior gestational event. We present a 44-year-old woman who had unusual pregnancy related history. The patient received her second spontaneous abortion at the age of 25 years and had suffered from choriocarcinoma in left board ligament at the age of 29 years. She admitted no more treatment after 3 courses of multiagent chemotherapy when serum β-hCG returned to normal. Then she had Full-term delivery, induced abortion at the ages of 32, 33 years. The patient had high serum levels of beta-human chorionic gonadotropin (6587 IU/L). Microscopically, the tumor was composed of mainly mononuclear tumor cells, grew in cords, nests, and sheets within which were aggregates of hyaline material. Most were with distinct cell borders, eosinophilic cytoplasm. Immunohistochemical staining revealed strong diffuse reactivity for cytokeratins (AE1/AE3, CK18), P63, focal reactivity for beta-human chorionic gonadotropin, human placental lactogen, and inhibin-alpha. The Ki-67 index was 77%. The histological and immunohistochemical features were characteristic of epithelioid trophoblastic tumor. This is the first reported case of these two gestational trophoblastic tumor happened on one person with the intervening normal pregnancy.
机译：上皮样滋养细胞肿瘤（ETT）是一种罕见的滋养细胞肿瘤，起源于绒毛膜型中间滋养细胞（ITs）。它通常与先前的妊娠事件相关。我们介绍了一位44岁的女性，她有不寻常的妊娠相关病史。该患者在25岁时第二次自发流产，并在29岁时患有左板韧带绒毛膜癌。当血清β-hCG恢复正常时，她接受了3个疗程的多剂化疗后不再接受治疗。然后她足月分娩，在32、33岁时引起流产。该患者血清中的β-人绒毛膜促性腺激素水平较高（6587 IU / L）。在显微镜下，该肿瘤主要由单核肿瘤细胞组成，生长于索状，巢状和片状，其中是透明物质的聚集体。多数具有明显的细胞边界，嗜酸性细胞质。免疫组织化学染色显示细胞角蛋白（AE1 / AE3，CK18），P63，β-人绒毛膜促性腺激素，人胎盘乳原和抑制素-α具有很强的弥散反应性。 Ki-67指数为77％。组织学和免疫组织化学特征是上皮样滋养细胞肿瘤的特征。这是这两个妊娠滋养细胞性肿瘤的第一例报道病例，发生在一名正常妊娠患者中。

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