Study of Synthetic Biomolecular Network in Escherichia Coli

Enakshi Guru; Sanghamitra Chatterjee

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Study of Synthetic Biomolecular Network in Escherichia Coli

机译：大肠杆菌中合成生物分子网络的研究

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The method for manipulating gene regulation in Escherichia coliis well established with toggle switch model. Theoretical study of the system has been done in details with two approaches deterministic and stochastic. This paper represents the role of biochemical parameters (like rate constant of expression of repressor) to determine the nature of stability. The robustness of the system increases with the higher order cooperativity of repression of promoters which in turns help to achieve the bistability in case of weaker promoter. The sudden switching from low to high state is clearly visible with the histogram. The time dependence of the concentration of protein has studied in two approaches. Effect of noise has been observed with changing system size and corresponding noise strength has been measured.

机译：利用拨动开关模型已经建立了操纵大肠杆菌基因调控的方法。已经用确定性和随机性两种方法对系统进行了详细的理论研究。本文代表了生化参数（如阻遏物表达的速率常数）对确定稳定性性质的作用。系统的鲁棒性随启动子抑制的更高阶合作性而增加，这反过来有助于在启动子较弱的情况下实现双稳态。从直方图可以清楚地看到从低电平到高电平的突然切换。蛋白质浓度的时间依赖性已通过两种方法进行了研究。随着系统尺寸的变化，已经观察到噪声的影响，并且已经测量了相应的噪声强度。

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《International Journal of Biophysics》 |2013年第1期|共13页
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Enakshi Guru; Sanghamitra Chatterjee;
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1. Mitogenic activities of synthetic Escherichia coli lipid A and a synthetic partial structure (tripalmitoyl pentapeptide) of E. coli lipoprotein. [J] . L Brade, W G Bessler, H Brade Infection and immunity . 1988,第5期

机译：合成大肠埃希氏菌脂质A和大肠杆菌脂蛋白的合成部分结构（三棕榈酰五肽）的致丝分裂活性。
2. Mitogenic activities of synthetic Escherichia coli lipid A and a synthetic partial structure (tripalmitoyl pentapeptide) of E. coli lipoprotein. [J] . L Brade, W G Bessler, H Brade Infection and immunity . 1988,第5期

机译：合成大肠埃希氏菌脂质A和大肠杆菌脂蛋白的合成部分结构（三棕榈酰五肽）的致丝分裂活性。
3. Inhibition of glycine cleavage system by pyridoxine 5′‐phosphate causes synthetic lethality in glyA yggS glyA yggS and serA yggS serA yggS in Escherichia coli Escherichia coli [J] . Ito Tomokazu, Hori Ran, Hemmi Hisashi, Molecular Microbiology . 2020,第1期

机译：吡哆醇5'-磷酸甘氨酸裂解系统对甘草γγγyggs和血清ygs血清大肠杆菌的合成致死性导致合成致死性
4. Using a Synthetic Probe to Study the Robustness of the Segregation Process of Protein Aggregates in Escherichia coli [C] . Andre S. Ribeiro, Samuel M. D. Oliveira International Conference on Bioinformatics, Biocomputational Systems and Biotechnologies . 2016

机译：使用合成探针研究蛋白质聚集体在大肠杆菌中的分离过程的鲁棒性
5. Mossbauer and EPR studies of the hydrogen-cluster of the iron-hydrogenases from C. pasteurianum and of synthetic complexes designed to model the iron sites of the [(2)iron](H)-subcluster and Mossbauer studies of the transcription factor FNR of Escherichia coli. [D] . Popescu, Victoria-Codrina. 2000

机译：Mossbauer和EPR研究巴氏梭菌铁氢酶的氢簇以及合成复合物以模拟[（2）iron]（H）-亚簇的铁位点，Mossbauer研究转录因子FNR大肠杆菌。
6. Two New Plasmid Post-segregational Killing Mechanisms for the Implementation of Synthetic Gene Networks in Escherichia coli [O] . Alex J.H. Fedorec, Tanel Ozdemir, Anjali Doshi, 2019

机译：两种新的质粒分离后杀死机制用于在大肠杆菌中实现合成基因网络
7. Two New Plasmid Post-segregational Killing Mechanisms for the Implementation of Synthetic Gene Networks in Escherichia coli [O] . Alex J.H. Fedorec, Tanel Ozdemir, Anjali Doshi, 2019

机译：两种新的质粒杀菌杀伤机制，用于在大肠杆菌中实施合成基因网络
8. "Studies on the nature of the genetic material transferred during conjugation in Escherichia coli." and "Genetic and biochemical studies on the cell-free formation of tryptophan synthetase in Escherichia coli." [R] . 1963

机译：“在大肠杆菌结合过程中转移的遗传物质的性质研究。”和“在大肠杆菌中无色素形成色氨酸合成酶的遗传和生化研究”。

Study of Synthetic Biomolecular Network in Escherichia Coli

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