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首页> 外文期刊>International Journal of Biophysics >On the Mechanisms of Wound Healing by Magnetic Therapy: The Working Principle of Therapeutic Magnetic Resonance
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On the Mechanisms of Wound Healing by Magnetic Therapy: The Working Principle of Therapeutic Magnetic Resonance

机译：磁疗伤口愈合的机制：磁共振治疗的工作原理

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Magnetic resonance therapy is innovative magnetic based strategy that, in these years, has received significant attention thanks to its positive medical effects. Clinical studies have shown that application of this therapy significantly accelerates wound healing and, in particular, healing of the diabetic foot disease. The aim of this paper is to formulate the working principle of this therapy. We analyse experimental data on biological effects produced by magnetic fields. Based on this, we show that there is a hierarchy of the possible physical mechanisms, which can produce such effects. We suggest that the mutual interplay between these mechanisms can lead to a synergetic outcome, which can affect the physiological state of the organism. Taking into account the non-thermal character of the magnetic therapy and experimental data on the tight connection between various diseases (including the wound processes) and changes in the redox processes, we study theoretically effects of magnetic fields on soliton mediated charge transport during the redox processes. We show that electrons bound in nonlinear soliton states in macromolecules, are sensitive to weak magnetic fields and change their dynamical properties. These changes affect charge transport and can facilitate redox processes. We suggest that enhancement of the redox processes launches the chain of biochemical and physiological changes which can stimulate the wound healing and healing of the organism in general. These non-thermal resonant mechanisms of the biological effects of magnetic fields, analysed in the paper, are summarized as the working principle of the magnetic resonance therapy. We support our approach by some biological and histological data (both in vitro and in vivo ) and by some clinical data. The knowledge of this working principle can provide information useful for optimizing magnetic therapy treatment protocols, and can be used as the guidelines for a further, pivotal clinical investigations related to therapies based on magnetic fields.
机译：磁共振疗法是一种创新的基于磁疗的策略，由于其积极的医学效果，近年来受到了广泛的关注。临床研究表明，该疗法的应用可显着加速伤口愈合，尤其是糖尿病足疾病的愈合。本文的目的是制定这种疗法的工作原理。我们分析了磁场产生的生物效应的实验数据。基于此，我们表明存在可能产生这种影响的可能物理机制的层次结构。我们建议这些机制之间的相互影响可以导致协同结果，从而影响生物体的生理状态。考虑到磁疗的非热特性以及各种疾病（包括伤口过程）与氧化还原过程变化之间紧密联系的实验数据，我们在理论上研究了磁场对氧化还原过程中孤子介导的电荷传输的影响流程。我们表明，电子在大分子中以非线性孤子状态束缚，对弱磁场敏感并改变其动力学特性。这些变化影响电荷传输，并可以促进氧化还原过程。我们认为，氧化还原过程的增强启动了生化和生理变化链，通常可以刺激伤口的愈合和生物体的愈合。本文分析了磁场的生物效应的这些非热共振机理，归纳为磁共振治疗的工作原理。我们通过一些生物学和组织学数据（体外和体内）和某些临床数据来支持我们的方法。该工作原理的知识可以为优化磁疗治疗方案提供有用的信息，并且可以用作与基于磁场的疗法相关的进一步关键临床研究的指南。

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