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首页> 外文期刊>International Journal of Biomedical Science >Voltammetric Determination of Cyproterone Acetate in Pharmaceutical Preparations
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Voltammetric Determination of Cyproterone Acetate in Pharmaceutical Preparations

机译：伏安法测定药物制剂中醋酸环丙孕酮的含量

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The voltammetric behaviour of cyproterone acetate (CPA) was studied using direct current (DCt) and differential pulse polarography (DPP). The drug manifests cathodic waves over the pH range of 4-11.8. In Britton-Robinson buffer (BRb) of pH 10, the diffusion current-concentration relationship was found to be rectilinear over the range 3.2-32 μg/mL and 0.5-14 μg/mL using DCt and DPP modes, respectively, with minimum limits of detection (LOD) of 0.13 μg/mL using the DDP. The diffusion-current constant (Id) was 9.29 ± 0.046 (n=9). The proposed method was successfully applied to the determination of the studied compound in its formulations. The mean percentage recoveries in tablets were 99.48 ± 1.25 and 100.01 ± 1.07 (n = 4) using DCt and DPP modes, respectively. The results obtained were in agreement with those of the reference method. A proposal for the electrode reaction was postulated.
机译：使用直流电（DCt）和差分脉冲极谱法（DPP）研究了醋酸环丙孕酮（CPA）的伏安行为。该药物在4-11.8的pH范围内表现出阴极波。在pH 10的Britton-Robinson缓冲液（BRb）中，使用DCt和DPP模式分别在最小限度下，发现扩散电流-浓度关系在3.2-32μg/ mL和0.5-14μg/ mL范围内呈直线关系DDP的检测（LOD）为0.13μg/ mL。扩散电流常数（Id）为9.29±0.046（n ＝ 9）。所提出的方法已成功地用于测定其制剂中所研究的化合物。使用DCt和DPP模式时，片剂的平均回收率分别为99.48±1.25和100.01±1.07（n = 4）。获得的结果与参考方法的结果一致。提出了电极反应的建议。

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