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首页> 外文期刊>International Journal of Clinical and Experimental Pathology >High expression of MAGE-A9 in tumor and stromal cells of non-small cell lung cancer was correlated with patient poor survival
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High expression of MAGE-A9 in tumor and stromal cells of non-small cell lung cancer was correlated with patient poor survival

机译：非小细胞肺癌中肿瘤和基质细胞中MAGE-A9的高表达与患者生存不良有关

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摘要

Melanoma associated antigen-A (MAGE-A) is an oncogene and correlated with tumor initiation and development. However the roles of MAGE-A9 in non-small cell lung cancer (NSCLC) are still unknown. We investigated MAGE-A9 mRNA expression in 18 tumor tissues of NSCLC by qRT-PCR and MAGE-A9 protein expression in 213 NSCLC samples of tissue arrays by immunohistochemical staining. We assessed the relationship between MAGE-A9 expression and clinical parameters. The results showed that the high expression of MAGE-A9 protein in NSCLC tumor cells were commonly present in squamous cell carcinomas (P = 0.030). It was also related to larger tumor diameter, lymph node metastasis and later stage grouping with TNM classification (all P < 0.05). Whereas the expression of MAGE-A9 in stromal cells was higher in squamous cell carcinomas as well. Cox regression univariate and multivariable analysis revealed that MAGE-A9 expression in tumor cells of NSCLC (P < 0.001) is an independent prognostic factor in five-year overall survival rate. We concluded that the molecular assessment of MAGEA9 could be considered to improve prognostic evaluation and to identify eligible patients for potential target therapy.
机译：黑色素瘤相关抗原-A（MAGE-A）是一种癌基因，与肿瘤的发生和发展相关。然而，MAGE-A9在非小细胞肺癌（NSCLC）中的作用仍然未知。我们通过qRT-PCR调查了18个NSCLC肿瘤组织中MAGE-A9 mRNA的表达，并通过免疫组织化学染色对了213个组织切片NSCLC样品中MAGE-A9蛋白的表达进行了研究。我们评估了MAGE-A9表达与临床参数之间的关系。结果表明，鳞癌中普遍存在NSCLC肿瘤细胞中MAGE-A9蛋白的高表达（P = 0.030）。它也与更大的肿瘤直径，淋巴结转移和TNM分类的晚期分组有关（所有P <0.05）。而在鳞状细胞癌中，基质细胞中MAGE-A9的表达也较高。 Cox回归单因素和多变量分析显示，NSCLC肿瘤细胞中MAGE-A9表达（P <0.001）是五年总生存率的独立预后因素。我们得出的结论是，可以考虑对MAGEA9进行分子评估，以改善预后评估并确定适合潜在目标疗法的患者。

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