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首页> 外文期刊>International Journal of Clinical and Experimental Pathology >Association of abcb1 polymorphisms and ulcerative colitis susceptibility
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Association of abcb1 polymorphisms and ulcerative colitis susceptibility

机译：abcb1基因多态性与溃疡性结肠炎易感性的关系

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Objective: Multi-drug resistance gene 1 (ABCB1) is closely related to bowel diseases. Therefore, our study was aimed to evaluate the correlation between ABCB1 polymorphisms (C1236T and C3435T) and ulcerative colitis (UC) susceptibility. Methods: A total of 61 UC patients and 64 healthy people participated in the study. Genotyping was conducted with the method of polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). χ2 test was used to evaluate the association of ABCB1 gene polymorphisms (C1236T and C3435T) and UC susceptibility. Results: For ABCB1 C1236T polymorphism, the frequencies of CC genotype and C allele were found higher in the cases than those in the controls (CC: 36.1% vs. 20.3%; C: 58.2% vs. 41.4%), which indicated that the CC genotype and C allele might increase the risk for UC (OR = 3.39, 95% CI = 1.28-8.97; OR = 1.97, 95% CI = 1.19-3.26). However, there were no statistical differences in the genotype or allele distribution of ABCB1 C3435T between the case and control group. Conclusion: The CC genotype and C allele of ABCB1 C1236T polymorphisms are significantly associated with UC susceptibility, so we conclude that ABCB1 C1236T polymorphisms might serve as genetic-susceptibility factors for UC. While, no remarkable relationship is observed between ABCB1 C3435T polymorphisms and UC.
机译：目的：多药耐药基因1（ABCB1）与肠道疾病密切相关。因此，我们的研究旨在评估ABCB1多态性（C1236T和C3435T）与溃疡性结肠炎（UC）易感性之间的相关性。方法：共有61名UC患者和64名健康人参加了这项研究。用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）的方法进行基因分型。 χ2检验用于评估ABCB1基因多态性（C1236T和C3435T）与UC易感性的关联。结果：对于ABCB1 C1236T多态性，发现病例中CC基因型和C等位基因的频率高于对照组（CC：36.1％对20.3％; C：58.2％对41.4％），表明CC基因型和C等位基因可能会增加发生UC的风险（OR = 3.39，95％CI = 1.28-8.97; OR = 1.97，95％CI = 1.19-3.26）。但是，病例与对照组之间的ABCB1 C3435T基因型或等位基因分布没有统计学差异。结论：ABCB1 C1236T多态性的CC基因型和C等位基因与UC易感性密切相关，因此我们认为ABCB1 C1236T多态性可能是UC的遗传易感性因素。同时，在ABCB1 C3435T多态性和UC之间没有观察到明显的关系。

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