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首页> 外文期刊>International Journal of Clinical and Experimental Pathology >HK2 is a radiation resistant and independent negative prognostic factor for patients with locally advanced cervical squamous cell carcinoma
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HK2 is a radiation resistant and independent negative prognostic factor for patients with locally advanced cervical squamous cell carcinoma

机译：HK2是局部晚期宫颈鳞状细胞癌患者的抗辐射且独立的阴性预后因子

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摘要

The mechanism by which overexpression of hexokinase 2 (HK2) indicates locally advanced cervical squamous cell carcinoma (LACSCC) with radio-resistance is still unknown despite being an independent biomarker of poor prognosis. Here, we retrospectively analyzed 132 female patients receiving radiotherapy for cervical squamous cell carcinoma including 85 radiation-sensitive cases and 47 radiation-resistant cases. The expression of HK2 was examined by immunohistochemistry. The percentage of high HK2 expression in the radiation-resistant group differed from the radiation-sensitive group with statistical significance (P < 0.001) even if divided into three subgroups including a lower 5-year progression free survival group (PFS) for comparison (P < 0.001). The Kaplan Meier curve analysis showed that there were differences between the two groups (P < 0.001). Therefore, this study proves a close relationship between HK2 expression and radio-resistance. Multivariate Cox regression analysis implied that HK2 was an independent prognostic indicator of cervical squamous carcinoma (HR (95% CI), 2.940 (1.609, 1.609); P = 0.002).
机译：尽管它是预后不良的独立生物标志物，但过表达己糖激酶2（HK2）提示局部晚期宫颈鳞状细胞癌（LACSCC）具有放射耐受性的机制仍然未知。在此，我们回顾性分析了132例接受宫颈鳞状细胞癌放射治疗的女性患者，其中包括85例放射敏感性病例和47例放射耐受性病例。通过免疫组织化学检查HK2的表达。即使分为三个亚组（包括较低的5年无进展生存期组（PFS））进行比较，抗辐射组中HK2高表达的百分比与辐射敏感组的差异也具有统计学意义（P <0.001）（P <0.001）。 Kaplan Meier曲线分析显示两组之间存在差异（P <0.001）。因此，该研究证明了HK2表达与抗辐射性之间的密切关系。多元Cox回归分析表明，HK2是宫颈鳞癌的独立预后指标（HR（95％CI），2.940（1.609，1.609）; P = 0.002）。

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