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首页> 外文期刊>International Journal of Clinical and Experimental Pathology >A case study of t(14;22)(q32;q11) involving immunoglobulin heavy and light chain in follicular lymphoma
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A case study of t(14;22)(q32;q11) involving immunoglobulin heavy and light chain in follicular lymphoma

机译：t（14; 22）（q32; q11）涉及滤泡性淋巴瘤免疫球蛋白重链和轻链的案例研究

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Chromosome 14 is the most frequently rearranged chromosome in non-Hodgkin lymphoma (NHL), with aberrations particularly involving the heavy-chain immunoglobulin gene (IGH) in the chromosome band 14q32. Several translocation partners have been described: t(14;18)(q32;21)/IGH-BCL2 in follicular lymphoma (FL), t(11;14) (q13;q32)/CCND1-IGH in mantle cell lymphoma, and t(8;14)(q24;q32)/MYC-IGH in Burkitt lymphoma. The chromosomal locus 22q11 contains two important genes associated with leukemia and lymphoma; one is BCR, which fuses with ABL from 9q34 in chronic myeloid leukemia, and the other is the immunoglobulin lambda gene (IGL), which is rarely involved in the translocations observed in B-cell NHL. The t(14;22)(q32;q11) translocation has been previously reported in 8 cases of B-cell NHL; however, the translocation between IGH and IGL has been experimentally confirmed using fluorescence in situ hybridization (FISH) for only 4 cases. Here, we describe the first case of FL with a t(14;22)(q32;q11)/IGH-IGL translocation confirmed using FISH analysis. The patient in our case report was immunocompromised and was treated for aplastic anemia with cyclosporine A (CsA). The patient was diagnosed with follicular lymphoma, most likely caused by CsA.
机译：14号染色体是非霍奇金淋巴瘤（NHL）中最常见的重排染色体，其畸变特别涉及14q32染色体带中的重链免疫球蛋白基因（IGH）。已经描述了几种易位伴侣：滤泡性淋巴瘤（FL）中的t（14; 18）（q32; 21）/ IGH-BCL2，套细胞淋巴瘤中的t（11; 14）（q13; q32）/ CCND1-IGH和伯基特淋巴瘤中的t（8; 14）（q24; q32）/ MYC-IGH。染色体基因座22q11包含两个与白血病和淋巴瘤相关的重要基因;一个是BCR，在慢性粒细胞白血病中与9q34的ABL融合，另一个是免疫球蛋白lambda基因（IGL），该基因很少参与B细胞NHL中观察到的易位。先前已有8例B细胞NHL病例报道了t（14; 22）（q32; q11）易位;然而，只有4例使用荧光原位杂交（FISH）实验证实了IGH和IGL之间的易位。在这里，我们描述了通过FISH分析证实的t（14; 22）（q32; q11）/ IGH-IGL易位的FL的第一种情况。本病例报告中的患者免疫功能低下，并用环孢霉素A（CsA）治疗再生障碍性贫血。患者被诊断出滤泡性淋巴瘤，很可能是由CsA引起的。

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