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首页> 外文期刊>International Journal of Clinical and Experimental Pathology >Expression of NF-?oB-inducing kinase in breast carcinoma tissue and its clinical significance
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Expression of NF-?oB-inducing kinase in breast carcinoma tissue and its clinical significance

机译：NF-κoB诱导激酶在乳腺癌组织中的表达及其临床意义

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Objective: To investigate the expression of nuclear factor-κB-inducing kinase (NIK) in breast carcinoma tissue and tumor-adjacent normal breast tissue and evaluate its clinical significance. Methods: Surgically resected tissue specimens were collected from 82 patients with breast carcinoma who underwent surgical treatment at our hospital from March 2001 to December 2009. The diagnoses of all patients were confirmed by postoperative pathological examinations. NIK protein expression in breast carcinoma tissue and adjacent normal breast tissue was detected by immunohistochemistry; the association between NIK expression and the clinicopathological features and prognosis of patients with breast carcinoma was examined. Results: The positive expression rate of NIK in breast carcinoma tissue was significantly higher than that in normal tissue (63.4% vs. 25.6%, P < 0.05). Additionally, NIK expression showed no relationship to the tumor size, age, degree of differentiation, or pathological type; however, it showed a significant correlation with lymph node metastasis and the clinical stage of patients (P < 0.05). The five-year survival rate was significantly lower in breast carcinoma patients who were positive for NIK expression than in those who were negative for NIK expression (P = 0.006). Conclusion: NIK expression was significantly increased in the tumor tissue of patients with breast carcinoma, which may be an important factor that affects the prognosis of these patients.
机译：目的：探讨乳腺癌组织和癌旁正常乳腺组织中核因子-κB诱导激酶（NIK）的表达及其临床意义。方法：收集2001年3月至2009年12月在我院接受手术治疗的82例乳腺癌患者的手术切除组织标本，所有患者均经术后病理检查确诊。免疫组织化学检测NIK蛋白在乳腺癌组织及邻近正常乳腺组织中的表达。研究了NIK表达与乳腺癌患者临床病理特征和预后之间的关系。结果：NIK在乳腺癌组织中的阳性表达率明显高于正常组织（63.4％vs. 25.6％，P <0.05）。此外，NIK表达与肿瘤的大小，年龄，分化程度或病理类型无关。然而，它与淋巴结转移和患者的临床分期显示显着相关性（P <0.05）。 NIK表达阳性的乳腺癌患者的5年生存率显着低于NIK表达阴性的乳腺癌患者的5年生存率（P = 0.006）。结论：NIK在乳腺癌患者肿瘤组织中的表达明显升高，这可能是影响这些患者预后的重要因素。

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