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首页> 外文期刊>International Journal of Clinical and Experimental Medicine >Efficacy of prophylactic intravenous ondansetron on the prevention of hypotension during cesarean delivery: a dose-dependent study
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Efficacy of prophylactic intravenous ondansetron on the prevention of hypotension during cesarean delivery: a dose-dependent study

机译：预防性静脉使用恩丹西酮预防剖宫产时低血压的作用：剂量依赖性研究

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Objective: This study was to determine the optimal dosage of ondansetron for preventing maternal hypotension during cesarean delivery. Methods: One hundred and fifty parturient women scheduled for elective cesarean section were randomly assigned to five groups (n=30). Five minutes prior to spinal anesthesia, women were injected with 5 ml of physiological saline (S), 2 mg (O2), 4 mg (O4), 6 mg (O6), or 8 mg (O8) of ondansetron in saline, respectively. Maternal blood pressure and heart rate were measured at 2-min intervals for 30 min. The serum parameters in umbilical cord blood were analyzed after delivery. Results: Compared with group S, the incidence of maternal hypotension was significantly lower in groups O4 and O6 (emP/em < 0.05). The umbilical venous pH was significantly higher in group O4 (emP/em < 0.05); while the partial pressure of carbon dioxide (Pcosub2/sub) was significantly lower in groups O4, O6, and O8 (emP/em < 0.05); and the bicarbonate (Hcosub3/subsup-/sup) and base excess in extracellular fluid (BEecf) were significantly lower in groups O6 and O8 (emP/em < 0.05). Moreover, minimal changes of systolic blood pressure, diastolic blood pressure, and mean arterial blood pressure were observed in group O4 (emP/em < 0.05). Conclusion: The optimal dose of ondansetron preloading was 4 mg during cesarean delivery.
机译：目的：本研究旨在确定恩丹西酮在预防剖宫产时预防母亲低血压的最佳剂量。方法：将150例计划行剖宫产的产妇随机分为5组（n = 30）。脊髓麻醉前五分钟，分别向妇女注射生理盐水中的5 ml生理盐水（S），2 mg（O2），4 mg（O4），6 mg（O6）或8 mg（O8）的恩丹西酮。 。每隔2分钟测量一次孕妇的血压和心率，持续30分钟。分娩后分析脐带血中的血清参数。结果：与S组相比，O4和O6组的孕妇低血压发生率显着降低（ P ＆＃x0003c; 0.05）。 O4组的脐静脉pH值明显升高（ P ＆＃x0003c; 0.05）; O4，O6和O8组的二氧化碳分压（Pco 2 ）显着降低（ P ＆＃x0003c; 0.05）; O6和O8（ P ＆＃）组的细胞外液（BEecf）中的碳酸氢根（Hco 3 -）和碱过量显着降低x0003c; 0.05）。此外，O4组的收缩压，舒张压和平均动脉压变化最小（ P ＆＃x0003c; 0.05）。结论：剖宫产时恩丹西酮预加载的最佳剂量为4 mg。

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