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首页> 外文期刊>International Journal of Clinical and Experimental Medicine >116 cases of neonatal early-onset or late-onset sepsis: A single center retrospective analysis on pathogenic bacteria species distribution and antimicrobial susceptibility
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116 cases of neonatal early-onset or late-onset sepsis: A single center retrospective analysis on pathogenic bacteria species distribution and antimicrobial susceptibility

机译：116例新生儿早发型或迟发型脓毒症：病原菌种类分布和耐药性的单中心回顾性分析

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emPurpose:/em The aim of this study was to explore the risk factors, clinical symptoms, hematological parameters, causative pathogen and antibiotic susceptibility of neonatal sepsis in a Chinese NICU. emMethods:/em A retrospective survey was conducted on 116 cases of neonatal sepsis in NICU at the Maternal and Child Care Hospital in Shenzhen, China from January 2009 to December 2012. Patients were divided into early-onset sepsis (EOS) and late-onset sepsis groups according to their positive blood culture occurrence time (in the first 7 days of life or later). emResults:/em 116 cases of neonatal sepsis were divided into early-onset sepsis (EOS) group and late-onset sepsis (LOS) group. There was significant difference for risk factors like peripherally insertion central catheter (PICC) between two groups. The clinical symptoms or laboratory results such as chilly periphery, fever, jaundice, platelet and hemoglobin also had between-group differences. The most common responsible pathogenic bacteria species present in EOS group was Coagulase-negative Staphylococcus (CoNS). Among those CoNS Staphylococcus epidermidis provided 24.24%, and Staphylococcus haemolyticus contributed 13.63%. Both were sensitive to vancomycin, teicoplanin and linezolid. The most common responsible pathogenic bacteria species in LOS group was Staphylococcus epidermidis (16%). Antimicrobial susceptibility in EOS group is higher than in LOS group. emConclusion:/em PICC is a bigger risk factor for neonatal late-onset sepsis. Staphylococcus epidermidis was the leading pathogen present in neonatal sepsis in a tertiary maternal & child care hospital in southern China. Vancomycin, teicoplanin and linezolid may be the best choice to management of neonatal sepsis.
机译：目的：本研究旨在探讨中国新生儿重症监护室（NICU）新生儿败血症的危险因素，临床症状，血液学参数，病原菌和抗生素敏感性。 方法：回顾性调查了2009年1月至2012年12月在中国深圳妇幼保健院收治的新生儿重症监护病房（NICU）的116例脓毒症患者。 ）和迟发性败血症组，要根据他们的阳性血培养发生时间（在生命的前7天或更晚）进行。 结果：将116例新生儿败血症分为早期发作脓毒症（EOS）组和晚期发作败血症（LOS）组。两组之间的风险因素有显着差异，例如外周中心插入导管（PICC）。临床症状或实验室检查结果如周围发冷，发烧，黄疸，血小板和血红蛋白也存在组间差异。 EOS组中最常见的负责病原菌是凝固酶阴性葡萄球菌（CoNS）。其中，表皮葡萄球菌占24.24％，溶血葡萄球菌占13.63％。两者均对万古霉素，替考拉宁和利奈唑胺敏感。 LOS组中最常见的负责病原菌是表皮葡萄球菌（16％）。 EOS组的抗生素敏感性高于LOS组。 结论： PICC是新生儿迟发性败血症的较大危险因素。表皮葡萄球菌是第三代产妇新生儿败血症中的主要病原体。中国南方的托儿所。万古霉素，替考拉宁和利奈唑胺可能是治疗新生儿败血症的最佳选择。

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