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首页> 外文期刊>International Journal of Clinical and Experimental Pathology >A huge nodular fasciitis in parapharygneal space in a 7-year-old girl: a case report and review of literature
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A huge nodular fasciitis in parapharygneal space in a 7-year-old girl: a case report and review of literature

机译：7岁女孩咽旁间隙巨大结节性筋膜炎：1例病例报告并文献复习

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摘要

Nodular fasciitis (NF) is a benign and reactive fibroblastic growth extending from the superficial fascia into the subcutaneous tissue or muscle, with a morbidity of less than 20% in children. We report a case of a 7-year-old girl presented with a 3-month history of snore and mouth breathing. Image findings demonstrated a large soft-tissue mass in the right parapharyngeal space. The lesion was successfully eradicated by surgical removal. Pathological analysis established NF as the final diagnosis. Histopathological findings were notable for a reactive spindle-cell process composed of proliferative fibroblasts with extravasated red blood cells and interstitial edema. Immunohistochemical stains showed that the lesional cells were positive for smooth muscle actin (SMA), muscle-specific actin (HHF35), and epithelial membrane antigen (EMA), and negative for S100 protein. No clinical evidence of recurrence was noticed after 2 months of follow-up. Being the first report of NF in the parapharyngeal space of a child, this rare pediatric case points out the importance for otolaryngologists to keep NF in mind for differential diagnosis to avoid unnecessary wide resection.
机译：结节性筋膜炎（NF）是一种良性的反应性成纤维细胞生长，从浅筋膜延伸到皮下组织或肌肉，儿童的发病率低于20％。我们报告了一个7岁女孩的案例，该女孩出现了3个月的打sn和口呼吸史。影像学发现表明右咽旁间隙有较大的软组织肿块。通过手术切除成功根除了病变。病理分析确定NF为最终诊断。组织病理学发现对于由增殖性成纤维细胞与外渗红细胞和间质性水肿组成的反应性纺锤状细胞过程是值得注意的。免疫组织化学染色显示，病变细胞的平滑肌肌动蛋白（SMA），肌肉特异性肌动蛋白（HHF35）和上皮膜抗原（EMA）呈阳性，而S100蛋白呈阴性。随访2个月后未发现复发的临床证据。作为儿童咽旁间隙中NF的首例报道，这一罕见的儿科病例指出，耳鼻喉科医师应牢记NF，以进行鉴别诊断以避免不必要的广泛切除。

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