Potentiometric Sensor for Quantitative Analysis of Pioglitazone Hydrochloride in Tablets Based on Theoretical Studies

Farnoush Faridbod; Mohammad Reza Ganjali; Ensieh Nasli-Esfahani; Bagher Larijani; Siavash Riahi; Parviz Norouzi

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Potentiometric Sensor for Quantitative Analysis of Pioglitazone Hydrochloride in Tablets Based on Theoretical Studies

机译：基于理论研究的盐酸吡格列酮片中电位传感器的定量分析

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Pioglitazone is a prescription drug of thiazolidinedione group with hypoglycemic action. Based on thecomputiational studies, pioglitazone-tetraphenyl borate was selected as a suitable ion-pair reagent in-5 -2 -1 making pioglitazone potentiometric PVC membrane sensor. A wide linear range of 10 -10 mol L ,-6 -1 low detection limit of 6.010 mol L , and fast response time of ~20 s are characterizations of theproposed sensors. Validation of the method shows suitability of the sensor for application in thequality control analysis of pioglitazone hydrochloride in pure and pharmaceutical formulation.

机译：吡格列酮是噻唑烷二酮组的处方药，具有降血糖作用。在计算机研究的基础上，选择吡格列酮-硼酸四苯酯作为制备吡格列酮电位PVC膜传感器的-5 -2 -1合适的离子对试剂。 10 -10 mol L的宽线性范围，-6 -1 -1的低检测限和6.010 mol L的低检测响应时间以及〜20 s的快速响应是所提出传感器的特征。该方法的验证表明该传感器适用于纯吡咯烷酮和药物制剂中盐酸吡格列酮的质量控制分析。

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《International Journal of Electrochemical Science》 |2010年第6期|共15页
作者
Farnoush Faridbod; Mohammad Reza Ganjali; Ensieh Nasli-Esfahani; Bagher Larijani; Siavash Riahi; Parviz Norouzi;
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Potentiometric Sensor for Quantitative Analysis of Pioglitazone Hydrochloride in Tablets Based on Theoretical Studies

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