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首页> 外文期刊>International Journal of Electrochemical Science >Potentiometric and Conductometric study of complex formations between Norfloxacin and Some metal ions and Norfloxacin determination in Dosage Forms
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Potentiometric and Conductometric study of complex formations between Norfloxacin and Some metal ions and Norfloxacin determination in Dosage Forms

机译：诺氟沙星与某些金属离子的复杂形成的电位和电导研究以及剂量形式的诺氟沙星测定

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The determination of proton ligand association constants of Norfloxacin(NFX) with different metalions viz; Ti(II), Ba (II), Sr(II), Co(II), Zr(IV), La(II), Pb(II), Cr(III),Fe(III) and Sn(II) bypotentiometric and conductometric methods, at ionic strength (μ= 0.01 M NaCl) was investigated andthe two logarithmic association constant values which calculated by the half–?method were 6.2and8.0. The stoichiometric of NFX–metal ion formed complexes was calculated to be 1:1, 1:2 and/or 1:3metal to ligand ratios are formed depending on the nature of the ligand and/or metal ions. The effect ofionic strength on stability constant of NFX, with some different metal ions was studied.Thestoichiometry of complexes formed in solution was confirmed by conductometric method.As well as,the species distribution (α) diagrams for NFX and their metal complexes which calculated as molefraction αML andαML2, were discussed.Also simple, precise, rapid and low–cost potentiometric andconductometric methods for determination of NFX(in pure form) were performed using sodiumhydroxide as titrant, at 25±1.0oC. The calibration graph was linear from 0.32–2.87 mg L–1 withdetection limit of 0.27 mg L–1, at SD was < 1.0, and correlation coefficient (r) was calculated to be0.9952.The proposed methods were successfully applied for NFXdetermination in pharmaceuticalformulations (tablets and eye drops) with no interferences from usual excipients. The analytical resultsobtained by applying the proposed methods compared very favorably with those obtained by theofficial method such as United States Pharmacopoeia and British Pharmacopoeia. The Recoveriesobtained of the proposed methods for determination of NFX in various tablet dosage forms werefound to be in the range of 95.8 to 103.3%, with standard deviations (SD) were within 0.16–0.24(n=5).
机译：诺氟沙星（NFX）与不同金属离子的质子配体缔合常数的测定Ti（II），Ba（II），Sr（II），Co（II），Zr（IV），La（II），Pb（II），Cr（III），Fe（III）和Sn（II）用电导法研究了离子强度（μ= 0.01 M NaCl）时，半峰法计算的两个对数缔合常数分别为6.2和8.0。根据配体和/或金属离子的性质，NFX-金属离子形成的配合物的化学计量计算为1：1、1：2和/或1：3。研究了离子强度对不同金属离子对NFX稳定常数的影响。通过电导法确定了溶液中形成的配合物的化学计量关系，并计算了NFX及其金属配合物的物种分布（α）图。还讨论了使用氢氧化钠作滴定剂在25±1.0oC下进行简单，精确，快速和低成本的电位法和电导法测定纯净NFX的方法。校正曲线在0.32–2.87 mg L–1范围内呈线性，检出限为0.27 mg L–1，在SD下<1.0，相关系数（r）计算为0.9952。不受常规赋形剂干扰的药物制剂（片剂和滴眼剂）。与使用诸如美国药典和英国药典等官方方法获得的分析结果相比，采用本方法所获得的分析结果非常有利。建议的测定各种片剂剂型中NFX的方法的回收率在95.8至103.3％的范围内，标准偏差（SD）在0.16-0.24（n = 5）之内。

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