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首页> 外文期刊>International Journal of Electrochemical Science >Plastic Sensor for Losartan Potassium Determination based on Ferroin and Ionic Liquid
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Plastic Sensor for Losartan Potassium Determination based on Ferroin and Ionic Liquid

机译：基于铁蛋白和离子液体的氯沙坦钾测定塑料传感器

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In this study, a potentiometric sensor based on a plastic-membrane was introduced for the determination of losartan potassium in pharmaceutical formulations. The sensing element contained an ion-pair, which was synthesized by the interaction of losartan potassium and 1,10 phenanthroline monohydrate. The best membrane sensor response was obtained by a membrane composed of 30.6% PVC, 61.4% o-NPOE, 7.5% ion-pair and 0.5% ionic liquid. The proposed method was successfully applied for the determination of losartan potassium in some formulations. The proposed sensor showed a linear dynamic range between 5.0×10–5 and 1.0×10–2 M of losartan potassium with a Nernstian slope of 62.0 ±1.0 mV per decade and a lower detection limit of 3.5×10–5 M. It displayed a fast response time of about 10 s, and a lifetime of about three weeks without any significant loss in its performance.
机译：在这项研究中，引入了一种基于塑料膜的电位传感器，用于测定药物制剂中的氯沙坦钾。传感元件包含一个离子对，该离子对是通过氯沙坦钾和1,10菲咯啉一水合物的相互作用合成的。通过由30.6％PVC，61.4％o-NPOE，7.5％离子对和0.5％离子液体组成的膜可获得最佳的膜传感器响应。该方法成功用于某些制剂中氯沙坦钾的测定。拟议中的传感器显示出氯沙坦钾的线性动态范围为5.0×10-5至1.0×10-2 M，每十年的Nernstian斜率为62.0±1.0 mV，检测下限为3.5×10-5M。快速响应时间约为10 s，使用寿命约为三周，而性能没有任何重大损失。

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