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Immobilization-Free Strategies for Designing of DNA-Based Electrochemical Biosensors

机译:基于DNA的电化学生物传感器设计的无固定化策略

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DNA has been widely utilized as a distinguish biomaterial for the development of sensitive biosensorsbased on its flexible structure and the specific interaction with other molecules, even cells. In recentyears, with the growth of nanotechnology and biosensors, DNA-based electrochemical devices haveundergone tremendous development in the field of molecular diagnosis. Importantly, immobilization-free electrochemical biosensors are increasing enormously due to their low cost, simple operation, andless time-consuming. Moreover, a wide range of signal-amplified methods have been used to improvethe performances of these biosensors. This review focuses on the recent advances in immobilization-free DNA-based electrochemical biosensors for the detection of DNA, microRNA, proteins, enzymesand other molecules.
机译:基于其灵活的结构以及与其他分子甚至细胞的特异性相互作用,DNA已被广泛用作开发敏感生物传感器的独特生物材料。近年来,随着纳米技术和生物传感器的发展,基于DNA的电化学装置在分子诊断领域得到了巨大发展。重要的是,由于无固定化的电化学生物传感器的低成本,简单的操作和较少的耗时,因此正大大增加。此外,已经使用多种信号放大方法来改善这些生物传感器的性能。这篇综述着重于无固定化的基于DNA的电化学生物传感器在检测DNA,微小RNA,蛋白质,酶和其他分子方面的最新进展。

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