Fabrication of Immunosensor Based on Au-silica Nanocomposite for Neuron-specific Enolase Detection

Bin Wang; Tao Liang; Jie Li; Hua Yu and Xiangyang Chu

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Fabrication of Immunosensor Based on Au-silica Nanocomposite for Neuron-specific Enolase Detection

机译：基于金-二氧化硅纳米复合材料的神经元特异性烯醇化酶免疫传感器的制备

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Neuron-specific enolase (NSE), a type of neuroendocrine molecule, is a putative serum marker for small-cell lung carcinoma. This work addressed the fabrication of a signal-enhanced, label-free, electrochemical immunosensor based on Au nanoparticle/mesoporous silica nanoparticles (Au-MSNs) for NSE determination. Because of the large number of active sites provided by the Au-SiO2 sensor, the modified immunosensor has a significantly enhanced sensitivity. Furthermore, during quantitative NSE detection, the sensor has a desirable linear relationship with the concentration (0.1-2000 ng/mL) and a detection limit of 0.05 ng/mL.

机译：神经元特异性烯醇化酶（NSE）是一种神经内分泌分子，是小细胞肺癌的公认血清标志物。这项工作解决了基于金纳米粒子/介孔二氧化硅纳米粒子（Au-MSNs）用于NSE测定的信号增强，无标记的电化学免疫传感器的制造。由于Au-SiO2传感器提供了大量的活性位点，因此改进的免疫传感器具有显着增强的灵敏度。此外，在定量NSE检测期间，传感器与浓度（0.1-2000 ng / mL）和0.05 ng / mL的检出限具有理想的线性关系。

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《International Journal of Electrochemical Science》 |2017年第8期|共9页
作者
Bin Wang; Tao Liang; Jie Li; Hua Yu and Xiangyang Chu;
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2. The Signal-Enhanced Label-Free Immunosensor Based on Assembly of Prussian Blue-SiO_2 Nanocomposite for Amperometric Measurement of Neuron-Specific Enolase [J] . Zhong Z., Shan J., Zhang Z., Electroanalysis . 2010,第21期

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3. An ultrasensitive immunosensor based on tri-armed star poly (glycidyl methacrylate) polymer-coated ITO-PET electrode for detection of neuron-specific enolase in human serum [J] . International journal of environmental analytical chemistry . 2020,第1a5期

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4. Label-free Paper-based Immunosensor with Graphene Nanocomposites for Electrochemical Detection of Follicle-stimulating Hormone [C] . Jinping Luo, Zhuang Kong, Yang Wang, Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2018

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5. Rapid and Sensitive Detection of Foodborne Pathogens Using Bio-Nanocomposites Functionalized Electrochemical Immunosensor with Dielectrophoretic Attraction [D] . Lee, Inae. 2017

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6. Paper-Based Surface-Enhanced Raman Scattering Lateral Flow Strip for Detection of Neuron-Specific Enolase in Blood Plasma [O] . Xuefei Gao, Peng Zheng, Sujan Kasani, -1

机译：纸基表面增强拉曼散射侧流条用于检测血浆中神经元特异性烯醇化酶
7. Paper-Based Surface-Enhanced Raman Scattering Lateral Flow Strip for Detection of Neuron-Specific Enolase in Blood Plasma [O] . -1

机译：基于纸的表面增强拉曼散射横向流动条，用于检测血液血浆中神经元特异性烯醇酶

Fabrication of Immunosensor Based on Au-silica Nanocomposite for Neuron-specific Enolase Detection

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