• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>International Journal of Electrochemical Science >Clenbuterol Determination in Pharmaceutical Formulation by Potentiometric Membrane Sensor
【24h】

Clenbuterol Determination in Pharmaceutical Formulation by Potentiometric Membrane Sensor

机译：电位膜传感器测定盐酸克伦特罗

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Clenbuterol is a selective 2-adrenoceptor agonist which has been known as a thermogenic drug. Thiswork introduces design and construction of a PVC membrane sensor for fast and simple determinationof Clenbuterol in pharmaceutical formulation. The designed electrochemical sensor responds based onion-pair exchange mechanism. Clenbuterol-Tetraphenyl borate was synthesized and used as sensingelement of the membrane. After a series of experiments, the best electrode performance was selectedwith a membrane composition of 30% PVC, 60% DBP, 2% room temperature ionic liquid and 8% ion- pair. Room temperature ionic liquid was used as an additive and improves the sensitivity of the sensor.This electrode has a rather fast (~34 s), stable and Nernstian response (57.50.4 mV/decade) in a wide-6 -2 -1 concentration range of 5.310 to 110 mol L , and applicable pH range of 3-6. Validation of themethod shows suitability of the sensors for analysis of Clenbuterol in pharmaceutical tablets. Thesensor shows good repeatability with RSD of 4.7%.
机译：盐酸克仑特罗是一种选择性的2-肾上腺素受体激动剂，被公认为是产热药物。这项工作介绍了用于快速简便地测定药物制剂中盐酸克伦特罗的PVC膜传感器的设计和构造。设计的电化学传感器响应基于洋葱对交换机制。盐酸克仑特罗-四苯硼酸酯被合成并用作膜的传感元件。经过一系列实验，选择了具有30％PVC，60％DBP，2％室温离子液体和8％离子对的膜组成的最佳电极性能。室温离子液体被用作添加剂并提高了传感器的灵敏度。该电极在较宽的-6 -2 -1范围内具有较快的响应时间（〜34 s），稳定的能斯特响应（57.50.4 mV /十倍）。浓度范围为5.310至110 mol L，适用的pH范围为3-6。该方法的验证表明传感器适用于分析药物片剂中的盐酸克仑特罗。该传感器显示出良好的重复性，RSD为4.7％。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号