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首页> 外文期刊>International Journal of Electrochemical Science >Chemically Modified Carbon Paste Sensor for Potentiometric Determination of Doxycycline Hydrochloride in Batch and FIA Conditions
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Chemically Modified Carbon Paste Sensor for Potentiometric Determination of Doxycycline Hydrochloride in Batch and FIA Conditions

机译：化学修饰碳糊传感器，用于分批和FIA条件下电位滴定法测定盐酸多西环素

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摘要

The utility of carbon paste electrode for the determination of doxycycline HCl modified withdoxycycline-tetraphenylborate ion-pair (in both batch and flow injection analysis (FIA) modes) is-5 demonstrated. The electrode revealed a Nernstian response over a wide concentration range (1.9910-3 -1 -5 -1 - 3.1910 mol L ). The detection limit of this sensor is 1.3310 mol L . The best performance wasobtained with carbon paste composition of 3% doxycycline-tetraphenylborate, 48.5% graphite and48.5% dibutyl phthalate (DBP). The sensor exhibits a very fast response time (9 s) and good selectivityin presence of inorganic cations, sugars and aminoacids. The proposed sensor shows a greatimprovement in comparison with other previously reported sensors. The sensor was successfullyapplied to monitoring of doxycycline in pure solution and pharmaceutical formulation (vibramycin andfarcodoxin capsoules) with recovery ranges from 97.30 - 105.37% and coefficient of variation from0.54 to 2.40%.
机译：碳糊电极用于测定强力霉素-四苯基硼酸根离子对修饰的强力霉素HCl的实用性（分批和流动注射分析（FIA）模式）为5。电极在很宽的浓度范围（1.9910-3 -1 -5 -1-3.1910 mol L）上显示出能斯特响应。该传感器的检出限为1.3310 mol L。用3％强力霉素-四苯基硼酸酯，48.5％石墨和48.5％邻苯二甲酸二丁酯（DBP）的碳糊组成可获得最佳性能。在存在无机阳离子，糖和氨基酸的情况下，该传感器具有非常快的响应时间（9 s）和良好的选择性。与其他先前报告的传感器相比，提出的传感器显示出很大的改进。该传感器已成功地应用于监测纯溶液和药物制剂（vibramycin和farcodoxin capsoules）中的多西环素，回收率范围为97.30-105.37％，变异系数为0.54至2.40％。

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