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首页> 外文期刊>International Journal of Electrochemical Science >Boron-doped Diamond Film Electrode as Voltammetric Sensor for Cetirizine
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Boron-doped Diamond Film Electrode as Voltammetric Sensor for Cetirizine

机译：硼掺杂金刚石薄膜电极作为西替利嗪的伏安传感器

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摘要

Electrochemical behaviour of cetirizine on bare boron-doped diamond electrode was investigated bycyclic voltammetry in supporting electrolytes with various values of pH. Signal of cetirizine is stronglyaffected by pH value of media. It was found that cetirizine provides one well developed irreversibleoxidation peak at the potential of 1 V vs. Ag/AgCl in phosphate buffer solution (pH = 8) and noreduction peak. Oxidation process of cetirizine is limited by diffusion and involves equal number ofelectrons and protons. Kinetics of charge transfer was characterized by estimation of basic kineticparameters as formal potentials (1.310 – 0.821 V), charge transfer coefficients (0.18 – 0.30) andstandard heterogeneous rate constants (2.3 – 1.4 × 10-4 cm s-1). Analytical performance of this reactionwas examined by optimized differential pulse voltammetry. Rather low detection limit of 1.6 ? 10-8 Mwas achieved. This value is significantly lower than on glassy carbon electrode. The practicalapplicability of proposed sensing platform was confirmed by analysis of pharmaceutical preparates andhuman urine as typical real samples.
机译：通过循环伏安法研究了西替利嗪在裸硼掺杂金刚石电极上在各种pH值的支持电解质中的电化学行为。西替利嗪的信号受培养基pH值的强烈影响。发现西替利嗪在磷酸盐缓冲溶液（pH = 8）中相对于Ag / AgCl的电位为1 V时，提供了一个良好发展的不可逆氧化峰，并且没有还原峰。西替利嗪的氧化过程受到扩散的限制，并且涉及相等数量的电子和质子。电荷转移的动力学特征是通过估算基本动力学参数来表征，例如形式势（1.310 – 0.821 V），电荷转移系数（0.18 – 0.30）和标准的异质速率常数（2.3 – 1.4×10-4 cm s-1）。通过优化的差分脉冲伏安法检查了该反应的分析性能。较低的检测极限为1.6？达到10-8 Mwa。该值明显低于玻璃碳电极上的值。通过分析药物制剂和人尿作为典型的真实样品，证实了所提出的传感平台的实用性。

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